姓名：刘艺锦

职称：特聘研究员

招生方向：微生物与生化药学，化学生物学、生化与分子生物学、药物化学

研究方向：

1.  RNA分子的结构和催化机理

2.  小核酸药物开发

3.  核酸探针、核酸药物载体

4.  生物大分子的化学生物学、结构生物学

通讯地址：天津市津南区海河教育园区同砚路38号，南开大学药物化学生物学国家重点实验室 300350

电子邮件：yvliu@nankai.edu.cn

教师简介：

1999-2003  山东师范大学物理系  学士

2003-2008  中国科学院生物物理研究所 博士  （导师：饶子和 院士）

2008-2011  英国癌症研究中心中国学者计划 （Cancer Research UK China Fellow Program）

2011-2018  英国邓迪大学生命科学院 Senior Associate (David Lilley 院士团队）

2018-      南开大学药物化学生物学全国重点实验室特聘研究员, 药学院双聘教授，博导

主要研究内容：

刘艺锦博士长期从事有关具有催化功能的特殊RNA分子—核酶(ribozyme) 的分子结构、催化机理以及小核酸药物设计工作。其他研究方向包括荧光小分子在研究RNA分子的示踪折叠过程中的应用，具有重要意义的核酸酶的结构以及催化机理。研究手法包括结构生物学（晶体学、冷冻电镜）、化学生物学、单分子荧光及细胞生物学等相关技术。

近三年论文：

1: Fan C, Zhan X, Guo F, Li Q, Lu K, Shan X, Zhou Y, Ren M, Greenberg MM, Liu Y*, Zhou C*. Uridine Embedded within DNA is Repaired by Uracil DNA Glycosylase via a Mechanism Distinct from That of Ribonuclease H2. J Am Chem Soc. 2025 Apr

2;147(13):11574-11583.

2: Zhang J, Zhao M, Xi Z, Liu X, Feng L, Bai J, Zhan X, Zhang C, Midgley AC, Liu Y*. Pistol Ribozyme-Driven Catalytic Spherical Nucleic Acid Integrates Gene and

Chemotherapy for Enhanced Cancer Therapy. J Am Chem Soc. 2025 Mar

19;147(11):9424-9440.

3: Lu M, Cao Z, Xiong L, Deng H, Ma K, Liu N, Qin Y, Chen SB, Chen JH, Li Y,Liu Y*, Yu Z*. A hammerhead ribozyme selects mechanically stable conformations for

catalysis against viral RNA. Commun Biol. 2025 Feb 3;8(1):165.

4: Zhan X, Wilson TJ, Li Z, Zhang J, Yang Y, Lilley DMJ*, Liu Y*. The structure

and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme. Nat

Commun. 2024 Aug 5;15(1):6628.

5: Jia X, Tian J, Fu Y, Wang Y, Yang Y, Zhang M, Yang C*, Liu Y*. Identification

of AURKA as a Biomarker Associated with Cuproptosis and Ferroptosis in HNSCC.

Int J Mol Sci. 2024 Apr 16;25(8):4372.

6: Jia X, Wang Y, Yang Y, Fu Y, Liu Y*. Constructed Risk Prognosis Model

Associated with Disulfidptosis lncRNAs in HCC. Int J Mol Sci. 2023 Dec

18;24(24):17626.

7: Yang L, Jia X, Fu Y, Tian J, Liu Y*, Lin J*. Creation of a Prognostic Model

Using Cuproptosis-Associated Long Noncoding RNAs in Hepatocellular Carcinoma.

Int J Mol Sci. 2023 Jun 10;24(12):9987.

其他论文：

1: Wilson TJ, Liu Y, Li NS, Dai Q, Piccirilli JA, Lilley DMJ. Comparison of the

Structures and Mechanisms of the Pistol and Hammerhead Ribozymes. J Am Chem Soc.2019 May 15;141(19):7865-7875. doi: 10.1021/jacs.9b02141. Epub 2019 May 2.

2: Liu Y, Freeman AD, Dclais AC, Lilley DMJ. A monovalent ion in the DNA

binding interface of the eukaryotic junction-resolving enzyme GEN1. Nucleic

Acids Res. 2018 Nov 16;46(20):11089-11098.

3: Liu Y, Freeman A, Dclais AC, Gartner A, Lilley DMJ. Biochemical and

Structural Properties of Fungal Holliday Junction-Resolving Enzymes. Methods

Enzymol. 2018;600:543-568.

4: Liu Y, Lilley DMJ. Crystal Structures of Cyanine Fluorophores Stacked onto

the End of Double-Stranded RNA. Biophys J. 2017 Dec 5;113(11):2336-2343.

5: Liu Y, Wilson TJ, Lilley DMJ. The structure of a nucleolytic ribozyme that

employs a catalytic metal ion. Nat Chem Biol. 2017 May;13(5):508-513.

6: Wilson TJ, Liu Y, Domnick C, Kath-Schorr S, Lilley DM. The Novel Chemical

Mechanism of the Twister Ribozyme. J Am Chem Soc. 2016 May 18;138(19):6151-62.

7: Liu Y, Freeman ADJ, Dclais AC, Wilson TJ, Gartner A, Lilley DMJ. Crystal

Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep. 2015 Dec 22;13(11):2565-2575.

8: Liu Y, Wilson TJ, McPhee SA, Lilley DM. Crystal structure and mechanistic

investigation of the twister ribozyme. Nat Chem Biol. 2014 Sep;10(9):739-44.