姓名：张曼

职称：讲师

学科方向： 生药学

研究方向： 中医药的系统生物学与化学生物学

通讯地址：天津津南区海河教育园区同砚路38号，南开大学药学院

电子邮件：manzhang@nankai.edu.cn

教师简介：2012年9月至2016年7月就读于吉林大学药学专业，获理学学士学位；2016年9月至2022年12月于南开大学药学院药物分析学专业硕博连读，获理学博士学位。2023年入职南开大学药学院任教至今，参与复方药物与系统生物学实验室多项科研项目。

代表性论文：

1. Man Zhang; Xiaoyao Ma; Honglei Xu; Wenbo Wu; Xin He; Xiaoying Wang; Min Jiang; Yuanyuan Hou; Gang Bai; A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation., The FEBS Journal, 2020, 287(9): 1816-1829

2. Man Zhang; Lili Ye; Hao Huang; Dandan Cheng; Kaixin Liu; Wenbo Wu; Fukui Shen; Zhihong Jiang; Yuanyuan Hou; Gang Bai; Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti- infective efficacy, Journal of Nanobiotechnology, 2020, 18(1): 140

3.Man Zhang; Jing Cui; Fukui Shen; Lili Ye; Chuanjing Cheng; Yang Li; Qiuyang Zhang; Lin Niu; Yuanyuan Hou; Gang Bai; A novel mode of action for COX‐2 inhibition: Targeting ATPase domain of HSP90 induces ubiquitin degradation of new client protein COX‐2, Clinical and translational medicine, 2022, 12(1): e705

4.Man Zhang; Lili Ye; Chuanjing Cheng; Fukui Shen; Lin Niu; Yuanyuan Hou; Gang Bai; Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT, Nutrients, 2021, 13(12): 4462

5. Man Zhang; Chao Jia; Ji Zhuang; Yuanyuan Hou; Xiwen He; Wenyou Li; Gang Bai; Yukui Zhang; GSH-Responsive Drug Delivery System for Active Therapy and Reducing the Side Effects of Bleomycin, ACS Applied Materials & Interfaces, 2022, 14(1): 417-427