姓名：杨光
职称：教授，博士生导师，南开大学百名青年学科带头人
研究方向：药物化学，化学生物学，细胞生物学
电子邮件：guang.yang@nankai.edu.cn
教师简介：
杨光，教授，2006年在天津大学应用化学专业获得本科学位，2009年硕士毕业于天津大学药学院药物化学专业。同年10月前往英国格拉斯哥大学（University of Glasgow）化学系攻读博士学位。2013年6月获得有机化学博士学位。然后前往英国诺丁汉大学（University of Nottingham）化学系，进行药物化学的博士后训练。期间加入了欧洲药物化学联合发展项目（European IMI），开展创新药物分子的设计与研发。2016年7月加盟药学院，从事创新药物筛选与发现的研究工作。获得国家自然科学基金，国际合作重大专项，国家新药创制重大专项，天津市自然科学重点，面上。青年项目等多项基金的支持。作为通讯作者在Sci. Trans. Med.，Sci. Adv.，Angew. Chem.，APSB，Cancer Comm.，J. Med. Chem.等期刊发表SCI文章60余篇，授权专利50余项。主持发现多个创新药物分子并开展临床研究，获批临床5项。
项目组主要研究方向有：
（1）创新靶向蛋白降解技术的开发。
（2）重大疾病创新靶点的发现与分子机制研究。
（3）基于靶点的创新分子设计与筛选。
（4）创新候选药物分子临床前开发。
项目组长期招收“药物化学”和“分子生物学”专业的硕士、博士研究生及博士后研究员。
近期代表作：
² Lan Ma, Kun Zhang, Zixuan Zhang, Chenyang Wang, Mengyuan Ma, Ying Liu, Yanli Zhao, Ziqing Gong, Ning Liu, Mingming Wei, Xiang Liu, Jingfeng Zhou, Shuangwei Liu, Cheng Yang, Guang Yang. * USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts. Sci. Trans. Med. 2025, 17, eadt9100. (Cover story)
² Huayu Hu, Yubo Wang, Mengmeng Wang, Zixuan Zhang, Xiaoting Gu, Ruixia Sun, Xinqiang Liu, Ning Li, Na Ding, Weiya Li, Xingli Zhao, Chao Li, Ziqi Huang, Xin Wang, Xiru Li, Shuangwei Liu, Shuang Yang, Guang Yang. * Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for TripleNegative Breast Cancer Treatment. J. Med. Chem. 2025, 68, 20464−20486.
² Yang Ou, Kun Zhang, Qiuying Shuai, Chenyang Wang, Huayu Hu, Lixia Cao, Chunchun Qi, Min Guo, Zhaoxian Li, Jie Shi, Yuxin Liu, Siyu Zuo, Xiao Chen, Yanjing Wang, Mengdan Feng, Hang Wang, Peiqing Sun, Yi Shia, Guang Yang, * Shuang Yang. USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells. Acta Pharmaceutica Sinica B. 2025, 15, 2593-2611.
² Yubo Wang, Mengmeng Wang, Lan Ma, Yan Zhang, Yue Jiao, Shuxin Zhang, Yijie Yang, Jialu Li, Mingming Wei, Sheng Cao, Kun Zhang, Shuangwei Liu, Guang Yang*. Identification of a potent and selective CDK9 degrader as a targeted therapeutic option for the treatment of small-cell lung cancer. J. Med. Chem. 2025, 68, 2528−2550.
² Yubo Wang, Ruonan Wang, Yanli Zhao, Sheng Cao, Chen Li, Yanjie Wu, Lan Ma, Ying Liu, Yuhong Yao, Yue Jiao, Yukun Chen, Shuangwei Liu, Kun Zhang, Mingming Wei, Guang Yang*. Discovery of selective and potent ATR degrader for exploration its kinase-independent functions in acute myeloid leukemia cells. Angew. Chem. Int. Ed. 2024, 63, 202318568.
² Ziqi Huang, Kun Zhang, Yurui Jiang, Mengmeng Wang, Mei Li, Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang, Jia Chen, Jiefu Wang, Ning Liu, Xiang Liu, Shuangwei Liu, Mingming Wei, Guang Yang*. Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Acta Pharm Sin B. 2024, 14, 4001-4013. (Cover story)
² Yulin Liu, Liting Zheng, Ying Li, Lan Ma, Nan Zheng, Xinhua Liu, Yanli Zhao, Li Yu, Ning Liu, Shuangwei Liu, Kun Zhang, Jingfeng Zhou, Mingming Wei, Guang Yang*. Neratinib impairs function of m6A recognition on AML1-ETO pre-mRNA and induces differentiation of t (8;21) AML cells by targeting HNRNPA3. Cancer Lett. 2024, 594, 216980.
² Lan Ma, Kun Zhang, Ziqi Huang, Yuda Guo, Ning Liu, Jia Chen, Xinyue Wang, Ying Liu, Mei Li, Jinxiao Li, Shuangwei Liu, Guang Yang*. Development of novel Silicon-Based Hydrophobic Tags (SiHyT) for targeted proteins degradation. J. Med. Chem. 2024, 67, 21344-21363. (Cover story)
² Zelin Xu, Meichen Zhou, Yuer Feng, Ziyu Han, Yaoyao Li, Guang Yang, * Xin Wang, Kun Zhang, Shuangwei Liu. * Fe(iii)-triggered radical arylation of arene moieties from cyclopropanols to construct dibenzocyclohepta/octanones: synthesis of N-acetylcolchinol-O-methyl ether. Org. Lett. 2024, 26, 6950−6954. (Cover story)
² Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, ZhaoyangWang, Yuxin Liu, Qiuying Shuai, HangWang, Peiqing Sun, Yi Shi, Guang Yang* Shuang Yang. USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer. Cancer Communications. 2023, 43, 765–787.
² Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qing Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, Xiaoting Gu, Ting Xiao, Hui Huang, Shanshan Chen, Wen Ning, Guang Yang, * Honggang Zhou. PKM2 promotes pulmonary fibrosis by stabilizing TGF-b1 receptor I and enhancing TGF-b1 signaling. Sci. Adv. 2022, 8, eabo0987.
² Kun Zhang, Wei Song, Mingming Wei, Yue Sun, Ning Wang, Lan Ma, Xuan Yu, Ruolin Gao, Ruonan Wang, Yan Zhang, Nan Zheng, Ning Li, Linrong Mu, Zhiwen Tang, Xuechun Li, Guang Yang.* A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J. Med. Chem. 2021, 64, 15825−15845.
² Sheng Cao, Lan Ma, Yulin Liu, Mingming Wei, Yuhong Yao, Chen Li, Ruonan Wang, Ning Liu, Zhiqiang Dong, Xuechun Li, Ming Li, Xiaoji Wang, Guang Yang* Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J. Med. Chem. 2021, 64, 16497−16511. (Cover story)
² Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang, G. Yang. * A robust and facile method for desulfonation to amines. Org. Chem. Front. 2021, 8, 6182. (Cover story, HOT paper)
² Mingming Wei, Yunyun Zhou, Chong Li, Yuyu Yang, Tongtong Liu, Yulin Liu, Yujiao Wei,Ning Liu, Shuangwei Liu, Qianqian Wang, Sheng Cao, Yue Sun, Pengzhen Sheng, Cheng Lu, Xiang Liu, and Guang Yang. * 5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. J. Med. Chem. 2021, 64, 12537−12547. (Cover story)
² Yujiao Wei, Yanting Tang, Yunyun Zhou, Yuyu Yang, Yetong Cui, Xuan Wang, Yubo Wang, Yulin Liu, Ning Liu, Qianqian Wang, Chong Li, Hao Ruan, Honggang Zhou, Mingming Wei, Guang Yang. * Discovery and Optimization of a Novel 2H Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor. J. Med. Chem. 2021, 64, 9078−9099.