姓名：刘文娟

职称：副教授

学科方向：中药学

研究方向：中药化学生物学研究

通讯地址：天津市津南区海河教育园同砚路38号，南开大学药学院

电子邮件：liuwenjuan@nankai.edu.cn

教师简介

长期从事中医药现代化研究，聚焦中医药药效成分与作用机制不明的核心问题，利用化学生物学的研究方法深度解析中药性效关系的现代科学内涵。近5年主持国家自然科学基金青年项目、中国博士后特别资助项目和中国博士后面上项目等课题3项，同时作为骨干参与科技部重点研发计划、国家自然科学基金面上项目、天津市重点研发计划等课题5项；以第一或通讯作者在Chinese Chemical Letters、Acta Pharmacologica Sinica B、Phytomedicine等杂志发表SCI论文10余篇。

代表性论文：

1. Wenjuan Liu; Yixu Wang; Sihan Xu; Jiawei Li; Mengting Song; Qinghe Du; Zhenzhen Wang; Qianqian Wang; Min Jiang^*; Gang Bai^*; o-Phenanthrenequinone-mediated guanidinium nucleophilic attack of tanshinone IIA to Arg145 on Annexin A2 inhibits endothelial-monocyte adhesion and contributes to relieve atherosclerosis, CHINESE CHEMICAL LETTERS, 2025,112320

2. Yixu Wang; Jin Zhang; Sihan Xu; Junjie Li; Wenjuan Liu^*; Min Jiang^*; Gang Bai^*; Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses, PHYTOMEDICINE, 2025;142:156807

3. Wenjuan Liu; Junjie Li; Sihan Xu; Yixu Wang; Jiawei Li; Shou Wang; Li Fu^*; Min Jiang^*; Gang Bai^*; Phillyrin and its metabolites exert antipyretic effects by targeting the NAD⁺ binding domain of GAPDH, MDH2 and IDH2, PHYTOMEDICINE, 2024, 134: 155955

4. Junjie Li; Yixu Wang; Jiawei Li; Sihan Xu; Shou Wang; Wenjuan Liu^*; Li Fu^*; Min Jiang^*; Gang Bai; Phillyrin and its metabolites treat pulmonary embolism by targeting PLCß3 to inhibit platelet activation, JOURNAL OF ETHNOPHARMACOLOGY, 2024, 333: 118457

5. Wenjuan Liu; Wei Yang; Ruixue Niu; Longfei Cong; Min Jiang^*; Gang Bai^*; Costunolide covalently targets and inhibits CaMKII phosphorylation to reduce ischemia-associated brain damage, PHYTOMEDICINE, 2023, 115(2023): 154822-154822.

6. Wenjuan Liu; Zhenqiang Li; Simeng Chu; Xiaoyao Ma; Xiaoying Wang; Min Jiang^*; Gang Bai^*; Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism, ACTA PHARMACEUTICA SINICA B, 2022, 12(1): 135-148.