姓名：王东杰

职称：副教授

学科方向： 药学

研究方向： 系统生物学，过敏肿瘤学，抗肿瘤药理

通讯地址：天津市海河教育园同砚路38号

电子邮件：wangdongjie@nankai.edu.cn

教师简介：理学博士，现任南开大学药学院副教授。本科毕业于沈阳药科大学药理学专业，后于清华大学/北京协和医学院攻读博士学位，并赴美国加州大学圣地亚哥分校联合培养。主要研究方向涵盖系统生物学、肿瘤药理学、临床药学及抗肿瘤药物开发。近三年以第一作者或通讯作者身份发表JCR1区SCI论文9篇，平均影响因子超9.6，代表性成果发表于Acta Pharmaceutica Sinica B、International Journal of Surgery及Journal of Experimental & Clinical Cancer Research等权威期刊，Google Scholar引用逾370次。主持科研项目多项，包括国家自然科学基金青年项目、香港中文大学直接资助及国家重点实验室公开基金等，参与国家面上基金项目累计经费逾200万元。持有中国及香港发明专利各一项，并多次受邀在美国癌症研究协会年会、香港免疫年会等国际学术会议上进行报告交流。

近期论文发表情况

1. Zhang B, Cho WC, Leung PC, Wong CK*, Wang DJ*. Pan-Cancer Multi-Omics Profiling of MS4A2 Unveils Its Functional Landscape in Lung Adenocarcinoma. Int J Surg. 2025;111(11):7686-7697.

2. Wang DJ, Zhang B, Liu X, Kan LL, Leung PC, Wong CK. Agree to disagree: the contradiction between IL-18 and IL-37 reveals shared targets in cancer. Pharmacol Res. 2024;200:107072.

3.Wang DJ, Li W, Albasha N, et al. Long-term exposure to house dust mites accelerates  lungcancer development in mice. J Exp Clin Cancer Res. 2023;42(1):26.

4. Ji M#, Wang DJ#, Lin S, et al. A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models. Acta Pharm Sin B. 2022;12(2):774-786.

5. Zhang B, Cho WC, Wang DJ*. Abstract 5085: Network toxicology and single-cell RNA sequencing to reveal the mechanism of ethylene oxide inducing blood cancers.  JCR 1区，Cancer Research. 2025;85(8_Supplement_1):5085-5085. (会议期刊)

6. Zhang B, Leung PC, Cho WC*, Wong CK*, Wang DJ*. Targeting PI3K signaling in lung cancer: advances, challenges and therapeutic opportunities. J Transl Med. 2025;23(1):184.

7. Zhang B, Song XY, Cho WC, Wong CK*,Wang DJ*. Deciphering anticancer mechanisms of calycosin in lung adenocarcinoma through multi-omics: targeting smad3-mediated notch signaling in the tumor microenvironment. Cancers. 2025;17(9):1455.

8. Zhang B, Leung PC, Wong CK*, Wang DJ*. Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection. Environ Sci Eur. 2025;37(96).

9. Zhang B, Leung PC, Wong CK*, Wang DJ*. The immunomodulatory effects of vitamin D on covid-19 induced glioblastoma recurrence via the PI3K-AKT signaling pathway. Int J Mol Sci. 2024;25(23), 12952;

10.Wang DJ, Chan BC, Zhang B, Wong KC, Kan LL, Wong CK. Dark under the lamp: neglected biological pollutants in the environment are closely linked to lung cancer. Int J Mol Sci. 2024;25(6):3081.