姓名：李海龙

职称：副教授

学科方向：分子药理学，细胞生物学

招生方向：分子与细胞生物学，微生物与生化药学，生物工程与制药学

通讯地址：天津市津南区海河教育园同砚路38号南开大学药学院，300350

电话：022-85358566

电子邮件：hailongli@mail.nankai.edu.cn

【主要研究方向】

1. 肺间质病创新疾病靶点机制研究、创新药物及递送载体研发

2. 器官纤维化（肠道、肝脏、眼睛纤维化）创新靶点机制研究、创新药物及递送载体研发

【教师简介】

  2022年毕业于南开大学药学院，获博士学位，2025年南开大学药学院博士后出站，同年入职南开大学任副教授。主持和参与多项创新化药、生物药在抗肺纤维化中的作用机制研究与药物药效评价。主要研究方向为肺间质病及器官纤维化疾病机制研究、创新药物及递送载体研发。以第一或通讯作者在International Journal of Biological Sciences、Acta Pharmacologica Sinica等杂志发表SCI论文20余篇；主持国家自然科学基金青年项目1项，参与国家自然科学基金面上项目2项, 参与天津市应用基础研究项目1项; 入选天津市第一批博士后创新岗位人才项目。

【近期论文发表情况】

1. Dan Wu, Hailong Li, Lin Wang, Yayue Hu, Hong Huang, Jinhe Li, Ying Yang, Xi Wu, Xiaoman Ye, Ruiqi Mao, Jiahang Li, Xue Shi, Chunfeng Xie, Cheng Yang. Echinocystic acid inhibits sepsis-associated renal inflammation and apoptosis by targeting protein tyrosine phosphatase 1B. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113076. doi: 10.1016/j.intimp.2024.113076

2. Hailong Li§, Jinhe Li§, Yayue Hu§, Ruotong Zhang, Xiaoting Gu, Yiying Wei, Shanshan Zhang, Xuefen Chen, Luqing Wei, Xiaohe Li, Songtao Gu, Jin Jin, Hui Huang*, Honggang Zhou*, Cheng Yang*. FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis. International Journal of Biological Sciences, 2023.

3. Hailong Li§, Ruotong Zhang§, Yayue Hu§, Jinhe Li, Ying Yang, Dan Wu, Xiaoting Gu, Fubo Zhang*, Honggang Zhou*, Cheng Yang*. Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function. International Immunopharmacology, 2023.

4. Hailong Li§, Jinhe Li§, Ting Xiao§, Yayue Hu, Ying Yang, Xiaoting Gu, Ge Jin, Hailong Cao*, Honggang Zhou* and Cheng Yang. Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways. Frontiers in Pharmacology, 2022.

5. Hai-long Li§, Yi-ying Wei§, Xiao-he Li§, Shan-shan Zhang, Ruo-tong Zhang, Jin-he Li, Bo-wei Ma, Shuai-bo Shao, Zi-wei Lv, Hao Ruan, Honggang Zhou* and Cheng Yang. Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis. Acta Pharmacologica Sinica，2022.

6. Hailong Li, Rui Liu, Ruotong Zhang, Shanshan Zhang, Yiying Wei, Liang Zhang, Honggang Zhou, Cheng Yang. Protective Effect of Arbidol Against Pulmonary Fibrosis and Sepsis in Mice. Front Pharmacol. 2021 Jan 27:11:607075. doi: 10.3389/fphar.2020.607075.

7. 李海龙，张若彤，卫怡颖，张杉杉，马博威，李霄鹤*，周红刚*. 环状 RNA 在肺纤维化中的作用研究进展. 中国药理学与毒理学杂志，2022.