姓名：艾笑羽

职称：副教授

学科方向：药剂学

邮箱：aixiaoyu@nankai.edu.cn

通讯地址：南开大学药学院 天津市津南区海河教园同砚路38号 300350

课程讲授：《生物药剂学与药物代谢动力学》（本科），《药物递送系统的设计与应用》（本科），《新药立项与注册》（本科），《微生物与免疫学》（本科），《药物临床前评价》（研究生）

研究方向：(有制药工程名额）

1. 肺部药物递送系统治疗特发性肺纤维化的研究；

2. 肺部药物递送系统治疗特发性肺纤维化合并肺癌的研究；

3. 精油透皮制剂的研发；

教育经历：

2010年9月-2015年7月，沈阳药科大学，药剂学，博士

2006年9月-2010年7月，沈阳药科大学，基础药学理科基地班，本科

教师简介：

课题组主要研究方向为药物新剂型与新制剂的研究开发、肺部药物递送系统治疗特发性肺纤维化的研究、肺部药物递送系统治疗特发性肺纤维化合并肺癌的研究及精油透皮制剂的研发。

以第一作者或通讯作者在Theranostics等杂志上发表文章20余篇。承担了国家自然科学金青年项目和天津市自然科学基金等项目，作为研究骨干参与国家级科研项目2项（包括国家科技部重大新药创制科技重大专项1项、国家自然科学基金面上项目1项）。作为参与者进行了多个1类新药临床前研究，获批新药临床批件3件（包括南开大学首个临床批件证书）。教育部学位中心学位论文（抽检）评审专家，International Journal of Pharmaceutics、Biomaterials Science、RSC Advances和New Journal of Chemistry等多个期刊审稿人。担任“中国民族卫生协会药学分会-天津学组”、“天津药理协会-呼吸分会”和“沈阳药科大学学报”委员。

学术论文：

1. Hailong Li, Xi Wu, Xiaoyu Ai, Cheng Yang et al., Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis, Asian Journal of Pharmaceutical Sciences, 2026, 21(1).

2. Hongting. Liu, Conglu Zhao, Xiaoyu Ai et al., Macrophage membrane entrapped rapamycin-loaded TPGS/F127 micelles through intratracheal instillation for enhanced drug delivery and therapy to lung cancer with pulmonary fibrosis, International Journal of Pharmaceutics, vol. 674, p. 125429, Apr. 2025.

3. Yao. Sun. Conglu Zhao. Xiaoyu Ai et al., Bergenin and vitexin delivery platform using mouse lung fibroblasts-derived exosomes for bleomycin-induced pulmonary fibrosis therapy, International Journal of Pharmaceutics, p. 125750, May 2025.

4. Chaoyue Zheng, Keran Li, Xiaoyu Ai,  Xiaoting Gu et al.,A magnetic nanoparticles-based ligand fishing method coupled with parallel artificial membrane permeability assay for rapid discovery and analysis of GSNO reductase inhibitors with good membrane permeability from Salvia miltiorrhiza Bunge. International Journal of Biological Macromolecules 332 (2025) 148578.

5. Conglu Zhao; Liyuan Zhao; Xiaoyu Ai et al., Intratracheal instillation of chitosan-coated formononetin-loaded porous microspheres prolongs lung retention and improves the treatment in bleomycin-induced pulmonary fibrosis, European Journal of Pharmaceutical Sciences, 2025.

6. 215(107347)Xiaoting. Gu. Xiaohe Li. Xiaoyu Ai et al., The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist, Frontiers in Pharmacology, vol. 15, p. 1510903, Jan. 2025.

7. Zhilin. Luo. Yao Sun. Xiaoyu Ai et al., Treatment of Bleomycin-induced Pulmonary Fibrosis by Intratracheal Instillation Administration of Ellagic Acid-Loaded Chitosan Nanoparticles, AAPS PharmSciTech, vol. 26, no. 4, p. 94, Mar. 2025.

8. Hongting. Liu. Shihao Cai. Xiaoyu Ai et al., Formononetin-Loaded PLGA Large Porous Microparticles via Intratracheal Instillation for Bleomycin-Induced Pulmonary Fibrosis Treatment, AAPS PharmSciTech, vol. 26, no. 5, p. 112, Apr. 2025.

9. Xiaoting. Gu. Xiaohe Li. Xiaoyu Ai et al., Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist, Frontiers in Pharmacology, vol. 15, p. 1423175, Aug. 2024.

10. Zhichao. Liu. Zhigang Liu. Xiaoyu Ai et al., Zanubrutinib ameliorates experimental idiopathic inflammatory myopathy-associated interstitial lung disease by BTK/NF-κB signaling pathway, International Immunopharmacology, vol. 143, p. 113313, Dec. 2024.

11. Jianwei. Zhang. Xiujun Zhang. Xiaoyu Ai. et al., Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway, PLoS ONE, vol. 19, no. 7, p. e0305927, Jul. 2024.

12. Zhilin Luo; Liyuan Ji; Xiaoting Gu*; Xiaoyu Ai*; Cheng Yang*; Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement, AAPS PharmSciTech, 2023, 24(8).

13. Meng Jing; Ai Xiaoyu; Zhou Honggang*; Chen Shuang*; Sun Tao*; Yang Cheng*; USP5 promotes epithelial–mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma,Theranostics, 2019, 9 (2):573-587.

14. Ai Xiaoyu; Liu Huijuan; Sun Tao*; Zhou Honggang*; Yang Cheng*; Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action, Theranostics, 2017, 7 (2): 425–435.

15. Xiaoyu Ai; Jin Sun*; Lu Zhong; Star-Shape Redox-Responsive PEG-Shedda ble Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Tr iggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison, Macromolecular Bioscience, 2014, 14(10): 1415-1428.

16. Ai Xiaoyu; Zhong Lu; Niu Handong; He Zhonggui*, Thin-film hydrationpreparation method and stability test of DOX-loaded disulfide-linked polyethyleneglycol 5000-lysine-di-tocopherol succinate nanomicelles.Asian Journal of Pharmaceutical Sciences，2014, 9(5)：244-250.

授权专利情况：

1. 艾笑羽，周红刚，孙涛，杨光，张红丹，文霞，一种提高苯妥英银稳定性的方法及苯妥英银外用制剂，南开大学，CN107998071A。

2. 何仲贵; 孙进; 艾笑羽，单甲氧基聚乙二醇-二硫-二维生素E琥珀酸酯及其制备和应用，沈阳药科大学，CN103788366B。