姓名： 王欣

职称： 副教授

学科方向： 有机化学，糖化学

研究方向： 药物化学，糖化学

通讯地址：南开大学药学院314

电子邮件：wangxinnk@nankai.edu.cn

教师简介：

2004年9月～2007年7月   南开大学化学院 有机化学博士

2007年至今               南开大学药学院

2007年到南开大学药学院工作。主要讲授本科生及研究生的《有机化合物结构鉴定》的理论课程。目前主要从事天然产物家族全合成及其活性开发；铂类药物糖基化配合物的设计合成及其抗肿瘤活性研究。先后主持南开大学青年教师研究资助项目、国家自然科学基金青年基金项目、天津市自然科学基金面上项目等多项科研项目，并参与国家重大新药创制、国家自然科学基金、天津市重点项目等近十余项科研课题的研究。近几年在本领域发表多篇有代表性的SCI论文。

代表性论文：

1. Jing Ma, Qingpeng Wang, Xiande Yang,  Wenpei Hao, Zhonglv Huang, Jiabao Zhang, Xin Wang* and Peng George Wang*，Glycosylated platinum(IV) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects，Dalton Trans., 2016, 45, 11830.

2. Qingpeng Wang,a,b Zhonglv Huang,a,b Jing Ma,a,b Xiaolin Lu,a Xin Wang*a,b and Peng George Wang*，Design, synthesis and biological evaluation of a novel series of glycosylated Platinum(IV) complexes as antitumor agents，Dalton Trans., 2016, 45, 10366-10374.

3. Hongbo Zhang, Qingpeng Wang, Xin Ning, Hang Hang, Jing Ma, Xiande Yang, Xiaolin Lu, Jiabao Zhang, Yonghong Li, Congwei Niu, Haoran Song, Xin Wang*, and Peng George Wang*. Synthesis and Biological Evaluations of a Series of Thaxtomin Analogues. J. Agric. Food Chem., 2015, 63, 3734-3741.

4. Qing-Peng Wang, Hong-Bo Zhang, Xin Ning, Hang Hang, Zhong-Lv Huang, Hao-Ran Song, Xin Wang*，Peng George Wang*. Microwave-Assisted Construction of C-Hydroxydiketopiperazines using Lanthanum(III) Triflate. Asian J. Org. Chem., 2015, 4(2): 132-136.

5. Xibo Yan, Yue Zhang, Hongbo Zhang, Peng George Wang, Xiaogang Chua, Xin Wang*, Amphiphilic polyethylenimine (PEI) as highly efficient non-viral gene carrier, Org. Biomol. Chem., 2014, 12, 1975.

6. Hongbo Zhang, Xin Ning, Hang Hang, Xuyan Ru, Haichen Li, Yonghong Li, Lizhong Wang, Xiao Zhang, Shujing Yu, Yuanyuan Qiao, Xin Wang,* and Peng George Wang*, Total Synthesis of Thaxtomin A and Its Stereoisomers and Findings of Their Biological Activities. Org. Lett., 2013, Vol 15, No. 22, 5670-5673.

7. Wenjun Wang, Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang*, Lei Li*, Wei Zhao*, and Peng George Wang. Preparation of oligosaccharides by homogenous enzymatic synthesisi and solid phase extraction. Chemical Communications, 2011,47, 11240-11242.

8. Wang Wen-jun, CAO Chen-ming, JIN Chen, WANG Xin*, and Peng Wang George*, Kinetic studies on aniline-catalyzed carbohydrate oxime formation via real-time NMR. CHEM. RES. CHINESE UNIVERSITIES 2011, 27 (5).

9. Yan Xibo, Wang Xin*, Wang Peng*, High efficient and simple route to synthesize per-O-acetyl-P-glycoside. 2010, 43(6), 14-22.

10. Xin Wang, Liang Yin and Yongmei Wang*, Synthesis of new dimeric-PEG-supported cinchona ammonium salts as chiral phase transfer catalysts for the alkylation of Schiff base with water as the solvent. Tetrahedron: Asymmetry, 2001, 18(1), 108-114.

11. Xin Wang, Jian Lv and Yongmei Wang*, A novel N-acetophone cinchona ammonium salts as chiral phase transfer catalysts for the alkylation of Schiff base with water as the solvent. Journal of Molecular Catalysis: A Chemical, 2007, 279(1-2), 102-109.

12. Xin Wang, Xu-dong Chen and Yong-mei Wang*, Crystal structures of a series of asymmetrically synthesized a-amino acid precusors. Sturctural Chemistry, 2007, (18), 867-873.

13. Xia C, Zhang W, Zhang Y, Chen W, Nadas J, Severin R, Woodward R, Wang B, Wang X, Kronenberg M, Wang PG. The role of 3' and 4' hydroxyl groups in alpha-galactosylceramide stimulation of invariant natural killer T cells. ChemMedChem, 2009, Nov 4(11), 1810-5.

14. Wang Yongmei*, Wang Xin and Liu Juyan. The stereoselective epoxidation by new type of soluble polymer-supported catalysts. Chinese Journal of Synthetic Chemistry, 2004, 12, 101.

申请专利：

1. 具有抗癌活性的糖基化四价铂类化合物、制备方法及应用 201610049513.0

2. 用于肿瘤治疗的四价铂糖基配合物及其制备方法 201610084260.0

3. Thaxtomin A及其立体异构体的合成方法 201310514121.3