姓名：姜民
职称：教授
学科方向：中药学
研究方向：中药药效物质基础及机制研究
通讯地址：天津津南区海河教育园区同砚路38号
电子邮件：minjiang@nankai.edu.cn
教师简介：
长期从事中医药现代化研究工作。针对当前中医药药效成分不清，作用机制不明的关键瓶颈问题，构建了从系统生物学到化学生物学的研究模式，整合多种研究方法，逐层递进的揭示中药的作用物质基础及作用机制。主持国家自然科学基金项目5项、作为任务负责人承担重点研发计划项目2项。获得天津市科技进步一等奖、二等奖各1项，近年以第一或通讯作者发表SCI论文20余篇。
近期发表论文：
1. Wang Y, Zhang J, Xu S, Li J, Liu W, Jiang M, Bai G. Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses. Phytomedicine. 2025 Jul;142:156807.
2. Zhang K, Luan G, Zhang J, Wang S, Jiang M, Bai G. Ligustilide covalently binds to Cys254 of the creatine kinase, M-type protein, ameliorating acute myocardial ischemia by enhancing the creatine phosphate level. Phytomedicine. 2025 Apr;139:156532.
3. Chu S, Shen F, Liu W, Zhang J, Wang X, Jiang M, Bai G. Sinapine targeting PLCβ3 EF hands disrupts Gαq-PLCβ3 interaction and ameliorates cardiovascular diseases. Phytomedicine. 2024 Apr;126:155200.
4. Liu W, Li J, Xu S, Wang Y, Li J, Wang S, Fu L, Jiang M, Bai G. Phillyrin and its metabolites exert antipyretic effects by targeting the NAD+ binding domain of GAPDH, MDH2 and IDH2. Phytomedicine. 2024 Nov;134:155955.
5. Liu W, Yang W, Niu R, Cong L, Jiang M, Bai G. Costunolide covalently targets and inhibits CaMKII phosphorylation to reduce ischemia-associated brain damage. Phytomedicine. 2023 Jul;115:154822.
6. Liu W, Li Z, Chu S, Ma X, Wang X, Jiang M, Bai G. Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism. Acta Pharm Sin B. 2022 Jan;12(1):135-148.
7. Lu Y, Ji J, Chu S, Shen F, Yang W, Lei W, Jiang M, Bai G. CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta. Clin Transl Med. 2022 Jun;12(6):e907.
8. Jiang M, Wang X, Lv B, Lu Y, Ma X, Liu W, Bai G, Gao X. Psoralen induces hepatotoxicity by covalently binding to glutathione-S-transferases and the hepatic cytochrome P450. Phytomedicine. 2022 Sep;104:154165.
9. Chu S, Lu Y, Liu W, Ma X, Peng J, Wang X, Jiang M, Bai G. Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases. Phytomedicine. 2022 Sep;104:154325.