姓名：孟萌
职称：教授
电子邮箱：mengmeng@nankai.edu.cn
联系地址：天津市津南区同砚路38号南开大学药学院315
学科方向：药剂学
招生方向： 药物化学，制药工程
课程讲授：《药物发展简史》（大一课程），《生化分析与分子诊断》（大三课程），药剂学综合试验（本科生必修课），《学术规范及论文写作指导》（研究生必修课）
教育经历
2003年9月–2008年7月, 北京大学药学院，药剂学, 博士，导师：张强院士
1999年9月–2003年7月, 北京大学药学院，药学, 本科
工作经历
2022年12月–至今 南开大学药学院，教授
2010年12月–2022年12月，南开大学药学院, 副教授
2017年10月–2018年10月, 美国加州大学洛杉矶分校, 访问学者，合作导师：Prof. Hsian-Rong Tseng
2008年07月–2010年12月, 南开大学药学院，讲师
研究方向
1. 光学成像分子的合成
2. 光疗纳米递送体系的研究
3. 纳米免疫佐剂的开发
教师简介
课题组主要从事有机发光分子的设计、纳米递送及其在成像指导的药物设计和疾病诊疗等方面研究。通过调试分子的光敏特性和生物学效应，初步开展药效学评价和药代动力学研究，以发展具有开发前景的临床前候选成像、光疗分子或递送体系。参与撰写Taylor & Francis Group出版社《Multifunctional Hydrogels》其中一章。以第一作者或通讯作者在J. Am. Chem. Soc.，Small，Chem. Eng. J.，J. Control. Release, ACS AMI, Anal. Chem.等杂志上发表文章30余篇，授权专利4项。承担了国家自然科学基金面上项目、国家自然科学金青年项目和天津市自然科学基金等项目，作为研究骨干参与了科技部国际合作项目和国家863项目。Angew. Chem.，Adv. Mater.，ACS Nano等多个期刊审稿人。
学术兼职
天津市整合医学学会转化医学专委会委员
中国药学会生化与生物技术药物专业委员会青年委员
Targets期刊首届青年编委
中国博士后科学基金评审专家
教育部学位中心学位论文（抽检）评审专家
代表性论文
1. Yanqi Qiao, Mengfan Han, Hongli Fu, Yaying Xu, Yueping Bai, Shuo Wang, Jie Yu, Changjun Men, Yongmei Yin, Xiujie Zhao,* Rimo Xi,* and Meng Meng*, Mucus-Penetrating Nanoassembly as Potential Oral Phototherapeutic Formulation against Multi-Drug Resistant Helicobacter pylori Infection, Small 2023, 2306909.
2. Xiujie Zhao,§ Yan Ma,§ Jianhao Di, Yanqi Qiao, Jie Yu, Yongmei Yin, Rimo Xi,* and Meng Meng*, Synergetic Pyroptosis with Apoptosis Improving Phototherapy of Mitochondria-Targeted Cyanines with Superior Photostability, ACS Appl. Mater. Interfaces, 2024, https://doi.org/10.1021/acsami.3c19205.
3. Xiujie Zhao, Hongjie Zhao, Shuo Wang, Zhiwen Fan, Yan Ma, Yongmei Yin, Wei Wang, Rimo Xi,* and Meng Meng*, A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy, J. Am. Chem. Soc. 2021, 143, 20828−20836.
4. Bei Wang, Qi Gan, Yue Tong, Yanqi Qiao, Mengfan Han, Ruixiao Zhang, Quansheng Han, Chuanbing Li, Su Bai, Long Xu, Yongmei Yin, Chunze Zhang, Baatar Munkhtsetseg, Xiujie Zhao*, Meng Meng*, Rimo Xi,* A visual diagnostic detection of Helicobacter pylori and the gastric carcinoma-related virulence genes (cagA and vacA) by a fluorescent loop-mediated isothermal amplification (LAMP), Talanta 256 (2023) 124260.
5. Yanqi Qiao, Yan Ma, Yue Tong, Wenting Liu, Shuo Wang, Ying Zheng, Changjun Men, Jie Yu, Jie Pan, Dong Wan, Yongmei Yin, Xiujie Zhao,* Rimo Xi,* and Meng Meng*, Phototherapy and Mechanism Exploration of Biofilm and Multidrug-Resistant Helicobacter pylori by Bacteria-Targeted NIR Photosensitizer, Small 2022, 2205248.
6. Shuo Wang, Yueping Bai, Dayuan Wang, Yunqian Zhai, Yanqi Qiao, Xiujie Zhao, Yongmei Yin, Rimo Xi, Wei Wang, Wei Zhao*, Meng Meng*, Reversing tumor to “Hot”: A NIR light-triggered carrier-free nanoplatform for enhanced tumor penetration and photo-induced immunotherapy, Chem. Eng. J. 442 (2022) 136322.
7. Xiujie Zhao,*§ Shuo Wang § Yan Ma, Wenting Liu, Hongjie Zhao, Jianhao Di, Zhiwen Fan, Yongmei Yin, Ying Zheng, Rimo Xi,* and Meng Meng*, Synergistic Release of Photothermal Molecules from Nanocarriers Induced by Light and Hyperthermia Benefits Efficient Anticancer Phototherapy, Anal. Chem. 2022, 94, 17160−17168.
8. Dening Gu, Yanqi Qiao, Hongli Fu, Hongjie Zhao, Xinmin Yue, Shuo Wang, Yongmei Yin, Rimo Xi, Xiaoling Fu,* Xiujie Zhao,* and Meng Meng*, Size-Controllable DNA Origami-Stacked Gold Nanoparticles for Deep Tumor-Penetrating Therapy, ACS Appl. Mater. Interfaces 2022, 14, 33, 38048–38055.
9. Xinmin Yue, Yanqi Qiao, Dening Gu, Rui Qi, Hongjie Zhao, Yongmei Yin, Wei Zhao, Rimo Xi,* and Meng Meng*, DNA-Based pH Nanosensor with Adjustable FRET Responses to Track Lysosomes and pH Fluctuations, Anal. Chem. 2021, 93, 7250−7257.
10. Kai Wang, Ruixiao Zhang, Xinmin Yue, Zheng Zhou, Lihuan Bai, Yue Tong, Bei Wang, Dening Gu, Shuo Wang, Yanqi Qiao, Qian Liu, Xue Xue, Yongmei Yin, Rimo Xi*, Meng Meng*, Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, ACS Sens. 2021, 6, 1543−1551.
11. Yanqi Qiao, Qingqing Xue, Xinmin Yue, Yang Liu, Qian Liu, Xiujie Zhao, Dening Gu, Shuo Wang, Kai Wang, Yongmei Yin, Jing Li, Rimo Xi*, Meng Meng*, A DNA nanoscaffold-based electrochemical assay for sensitive determination of O-GlcNAc transferase (OGT) activity and its application in cell-permeable OGT inhibitors screening, Sensors Actuat. B-Chem. 334 (2021) 129665.
12. Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA, J. Control. Release 330 (2021) 483–492.
13. Xiujie Zhao, Zhiwen Fan, Yanqi Qiao, Yun Chen, Shuo Wang, Xinmin Yue, Tangliang Shen, Wenting Liu, Jie Yang, Heqi Gao, Xuelin Zhan, Luqing Shang, Yongmei Yin, Wei Zhao, Dan Ding, Rimo Xi*, Meng Meng*, AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780, ACS Appl. Mater. Interfaces 2020, 12: 16114–16124.
14. Xiujie Zhao, Yun Chen, Guiyu Niu, Dening Gu, Jianning Wang, Yanmei Cao, Yongmei Yin, Xiaogang Li, Dan Ding, Rimo Xi* and Meng Meng*, Photostable pH-Sensitive Near-Infrared Aggregation-Induced Emission Luminogen for Long-Term Mitochondrial Tracking, ACS Appl. Mater. Interfaces, 2019, 11: 13134–13139.
15. Xinmin Yue, Yanqi Qiao, Dening Gu, Zixuan Wu, Wenhui Zhao, Xiaoyu Li, Yongmei Yin, Wei Zhao, Deming Kong, Rimo Xi*, Meng Meng*, Reliable FRET-ON imaging of telomerase in living cells by a tetrahedral DNA nanoprobe integrated with structure-switchable molecular beacon, Sensors Actuat. B-Chem. 2020, 312, 127943.
16. Wei Liu, Wenxiu Yu, Xiaogang Li, Xiaoyong Zhao, Yu Zhang, Pei Song, Yongmei Yin, Rimo Xi, Meng Meng*, Pyrophosphate-triggered intermolecular cross-linking of tetraphenylethylene molecules for multianalyte detection, Sensors Actuat. B-Chem., 2018, 266:170–177.
17. Li Xiaogang#, Liu Wei#, Yue Xinmin, Song Pei, Yin Yongmei, Meng Meng*, Xi Rimo*, A competitive immunoassay using hapten-modified polydiacetylene vesicles for homogeneous and sensitive detection of sodium benzoate, Sensors Actuat. B-Chem., 2018, 258: 1060–1065.