姓名：吴茜

职称：特聘研究员，博导

招生方向：药物化学

研究方向：

1. 活性主族元素化合物设计、合成与应用；

2. 有机药物合成开发；

3. 生物荧光染料的开发。

通讯地址：天津市海河教育园区同砚路38号南开大学药学院320，300350

电子邮箱：wuqian@nankai.edu.cn

本课题组欢迎“申请-考核制博士”、统考和推免硕士研究生、优秀的博士后和研究助理加入，请直接联系wuqian@nankai.edu.cn

教师简介：吴茜，南开大学药学院、药物化学生物学国家重点实验室特聘研究员，博士生导师。2011年本科毕业于四川大学化学学院。2016年在四川大学获得有机化学学博士学位（导师：游劲松 教授）。随后，在南开大学周其林院士指导下开展博士后研究。2017年获德国洪堡奖学金，进入德国柏林工业大学Martin Oestreich教授（Warker Silicone奖获得者）课题组从事有机硅化学研究。2019年获日本学术振兴会JSPS奖学金，在名古屋大学Shigehiro Yamaguchi教授课题组进行基于主族元素的超高光稳定性荧光探针的研究。目前，以发表SCI论文十余篇，包括顶级学术期刊Science、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等。多篇被评为“VIP”论文。

代表性研究成果:

(1) Qian Wu, Elisabeth Irran, Robert Müller, Martin Kaupp, Hendrik F. T. Klare*, Martin Oestreich*, “Characterization of hydrogen-substituted silylium ions in the condensed phase”, Science, 2019, 365, 168. (Highlighted in SYNFACTS, 2019, 15, 1427. Commentary: Science, 2019, 365, 135; Nat. Rev. Chem., 2020, 4, 4.)

(2) Qian Wu†, Avijit Roy†, Guoqiang Wang, Elisabeth Irran, Hendrik F. T. Klare, Martin Oestreich*, “Synthesis of a Counteranion-Stabilized Bis(silylium) Ion”, Angew. Chem. Int. Ed., 2020, 59, 10523. (Highlighted as a "Very Important Paper (VIP)" by Angewandte Chemie.)

(3) Qian Wu, Avijit Roy, Elisabeth Irran, Zheng-Wang Qu,* Stefan Grimme, Hendrik F. T. Klare, Martin Oestreich*, “Catalytic Difunctionalization of Unactivated Alkenes with Unreactive Hexamethyldisilane through Regeneration of Silylium Ions”, Angew. Chem. Int. Ed., 2019, 58, 17307. (Highlighted as a "Very Important Paper (VIP)" by Angewandte Chemie. Highlighted in SYNFACTS, 2019, 15, 1427.)

(4) Qian Wu, Zheng-Wang Qu*, Lukas Omann, Elisabeth Irran, Hendrik F. T. Klare, and Martin Oestreich*, “Cleavage of Unactivated Si–C(sp3) Bonds with Reed’s Carborane Acids: Formation of Known and Unknown Silylium Ions”, Angew. Chem. Int. Ed., 2018, 57, 9176.

(5) Qian Wu, Yi Luo, Aiwen Lei*, Jingsong You*, “Aerobic Copper(II)-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles”, J. Am. Chem. Soc., 2016, 138, 2885. (Highlighed in SYNFACTS, 2016, 12, 0513.)

(6) Qian Wu, Chenglong Du, Yumin Huang, Xingyan Liu, Zhen Long, Feijie Song, Jingsong You*, “Stoichiometric to Catalytic Reactivity of the Aryl Cycloaurated Species with Arylboronic Acids: Insight into the Mechanism of Gold-Catalyzed Oxidative C(sp2)–H Arylation”, Chem. Sci., 2015, 6, 288.

(7) Dongbing Zhao,† Qian Wu,† Xiaolei Huang, Feijie Song, Taiyong Lv, Jingsong You*, “A General Method to Diverse Cinnolines and Cinnolinium Salts”, Chem. Eur. J., 2013, 19, 6239. († These authors contributed equally)

(8) Qian Wu, Dongbing Zhao, Xurong Qin, Jingbo Lan, Jingsong You*, “Synthesis of Di(hetero)aryl Sulfides by Directly Using Arylsulfonyl Chlorides as a Sulfur Source”, Chem. Commun., 2011, 47, 9188.

(9) Kaizhi Li, Qian Wu, Jingbo Lan, and Jingsong You*, “Coordinating Activation Strategy for C(sp3)–H/C(sp3)–H Cross-Coupling to Access β-Aromatic α-Amino Acids”, Nat. Commun., 2015, 6, 8404.

(10) Jiaxing Dong, Qian Wu, Jingsong You*, “Stoichiometric Copper or Silver Salt-Mediated Oxidative C–H/C–H Cross-Coupling Reactions”, Tetrahedron Lett., 2015, 56, 1591.

(11) Guangying Tan, Xiaolei Huang, Qian Wu, Luo-Qiang Zhang, Jingsong You*, “Rh(III)-Catalyzed Annulation of N-Methoxybenzamides with Ynesulfonamides at Room Temperature: A Practical and Efficient Route to 4-Aminoisoquinolone Derivatives”, RSC Adv., 2014, 4, 49186.

(12) Mingliang Li, Jiaxing Dong, Xiaolei Huang, Kaizhi Li, Qian Wu, Feijie Song, Jingsong You*, “Nickel-Catalyzed Chelation-Assisted Direct Arylation of Unactivated C(sp3)–H Bonds with Aryl Halides”, Chem. Commun., 2014, 50, 3944.

(13) Avijit Roy, Vittorio Bonetti, Guoqiang Wang, Qian Wu, Hendrik F. T. Klare, and Martin Oestreich*, Org. Lett., 2020, 22, 1213.

(14) Xurong Qin, Hu Liu, Dekun Qin, Qian Wu, Jingsong You,* Dongbing Zhao, Qang Guo, Xiaolei Huang, Jingbo Lan*, “Chelation-Assisted Rh(III)-Catalyzed C2-Selective Oxidative C–H/C–H Cross-Coupling of Indoles/Pyrroles with Heteroarenes”, Chem. Sci. 2013, 4, 1964.