姓名：侯媛媛
职称：教授
学科方向：生药学
研究方向：中药治疗呼吸系统疾病药物的化学物质基础与作用机制研究
通讯地址：天津市津南区海河教育园区同砚路38号
电子邮件：houyy@nankai.edu.cn
个人简介：
1999年毕业于中国药科大学药物分析专业，获理学学士学位。
1999～2002年 任职于天津药业股份有限公司（金耀集团）。
2002～2007年 就读于四川大学华西药学院药物分析专业，硕博连读，获理学博士学位。
2007年7月到南开大学药学院工作。主要讲授本科生《药物分析》的理论课程。科研方面主要集中在筛选复方中药的生物活性成分及其作用机制的研究。先后主持1项国家自然科学基金青年基金项目、3项国家自然科学基金面上项目，并参与重点研发计划项目、国家重大新药创制、国家自然科学基金重点项目、天津市重点项目、天津市科技支撑项目、教育部博士点基金项目等十余项科研课题的研究。近5年发表SCI论文50多篇，其中第一或通讯作者文章20余篇。
主持科技项目：
1. 甘草与天然β2受体激动剂治疗哮喘的协同作用机理研究（国家自然科学基金青年基金项目：81001682）
2. “甘草-桔梗”药对治疗气道炎症的协同作用机理研究（国家自然科学基金面上项目：81374046）
3. 清热解毒核心药对调节免疫配伍相须的分子机制研究（国家自然科学基金面上项目：81673616）
4. 基于氧化呼吸链的中医清热的化学物质基础及其生物学机制研究（国家自然科学基金面上项目：81973449）
代表性论文：
1. Weiyi Zhang, Jie Gao, Man Zhang, Wenjuan Liu, Xiaoyao Ma, Wei Lei, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai*. Cinnamaldehyde enhances anti-melanoma activity through covalently binding ENO1 and have synergy effects with dacarbazine. Cancers, 2020, 12: 311.
2. Chuanjing Cheng, Fukui Shen, Guoyu Ding, Aina Liu, Simeng Chu, Yuejiao Ma, Xiaotao Hou, Erwei Hao, Xiaoying Wang, Yuanyaun Hou*, Gang Bai*. Lepidiline A improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. Molecular Nutrition & Food Research, 2020, 64: 1900706.
3. Man Zhang, Xiaoyao Ma, Honglei Xu, Wenbo Wu, Xiaoying Wang, Min Jiang, Yuanyuan Hou* Gang Bai*. A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation. FEBS Journal, 2020, 287: 1816-1829.
4. Zhihua Wang, Wenbo Wu, Chenxiang Guan, Shuang Guo, Chaowen Li, Ruixue Niu, Jie Gao, Min Jiang, Liping Bai, Elaine Laihan Leung, Yuanyuan Hou*, Zhihong Jiang*, Gang Bai*. 20(s)-Protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysis. Acta Pharmaceutica Sinica B, 2020, 10(6): 1020-1035.
5. Man Zhang, Lili Ye, Wenbo Wu, Kaixin Liu, Hao Huang, Dandan Cheng, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhances cell membrane permeability, promotes antibiotic pulmonary targeting and improves anti-infect efficacy. Journal of Nanobiotechnology, 2020, 18: 140.
6. Shengnan Yang, Yuan Zhang, Fukui Shen, Xiaoyao Ma, Man Zhang, Yuanyuan Hou*, Gang Bai*. The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation. FEBS Letters, 2019, 593 (2): 175-186.
7. Yunbing Shen, Shengnan Yang, Xueyan Hu, Man Zhang, Xiaoyao Ma, Zhihua Wang, Yuanyuan Hou*, Gang Bai*. Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells. Journal of Functional Foods, 2019, 55: 296-304.
8. Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou*, Gang Bai*. Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins. Acta Pharmaceutica Sinica B, 2019, 9 (2): 294-303.
9. Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Ming Jiang, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. Quantitative proteomics combine with affinity MS revealed the molecular mechanism of ginsenoside anti-tumor effects. Journal of Proteome Research, 2019, 18 (5): 2100-2108.
10. Zhihua Wang, Unchol Kim, Jinbiao Liu, Chuanjing Cheng, Wenbo Wu, Shuang Guo, Yunjiang Feng, Ronald J. Quinn, Yuanyuan Hou*, Gang Bai*. Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs. Analytical and Bioanalytical Chemistry, 2019, 411(22): 5785-5797.
11. Xiaoyao Ma, Aina Liu, Wenjuan Liu, Zhihua Wang, Nianwei Chang, Suyun Li, Jiansheng Li, Yuanyuan Hou*, Gang Bai*. Analyze and identify Peiminine target EGFR improve lung function and alleviate pulmonary fibrosis to prevent exacerbation of COPD by phosphoproteomics analysis. Frontiers in Pharmacology, 2019, 10: 737.
12. Fukui Shen, Wenbo Wu, Man Zhang, Zhongyao Tang, Hao Huang, Jingrong Wang, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. The Micro-PET imaging demonstrates 3-O-β-D-glucopyranosyl platycodigenin as an effective metabolize improves the dosimetry of [18F]-Phillygenin in lung tissue. Frontiers in Pharmacology, 2019, 10: 1020.
13. Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang, Jie Gao, Yuanyuan Hou*, Gang Bai*. Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation. Biochemical Pharmacology, 2019, 170, 113660.
14. Xueyan Hu, Yunbing Shen, Shengnan Yang, Wei Lei, Cheng Luo, Yuanyuan Hou*, Gang Bai*. Metabolite identification of ursolic acid in mouse plasma and urine after oral administration by ultra-high performance liquid chromatography/quadrupole time-of flight mass spectrometry. RSC Advances, 2018, 8: 6532-6539.
15. Qingxin Cui‡, Yuanyuan Hou‡, Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao, Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng*, Gang Bai*. Biodistribution of arctigenin‑loaded nanoparticles designed for multimodal imaging. Journal of Nanobiotechnology, 2017, 15: 27.
16. Zhongyao Tang, Yuanyuan Hou*, Xueyan Hu, Aina Liu, Leefong Yau, Tiantian Tong, Zhihong Jiang, Gang Bai. Metabolite identification and pharmacokinetic study of platycodi radix (Jiegeng) in vivo. RSC Advances, 2017, 7: 37459-37466.
17. Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou*, Gang Bai*. Ursolic Acid, A Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation-Associated Downstream Signal Transduction. Molecular Nutrition & Food Research, 2017, 61(12): 1700332.
18. Jin Tao, Yuanyuan Hou*, Xiaoyao Ma, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Gang Bai*. An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica-Fritillaria usuriensis dropping pills for pulmonary diseases. BMC Complementary and Alternative Medicine. 2016 Jan 8; 16(1): 4.
19. Yuan Yuan Hou, Yan Nie, Bin Feng Cheng, Jin Tao, Xiao Yao Ma, Min Jiang, Jie Gao, Gang Bai*. Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. Acta Pharmaceutica Sinica B, 2016, 6(3): 212-221.
20. Guoyu Ding, Yuanyuan Hou*, Jiamin Peng, Yunbing Shen, Min Jiang, Gang Bai. On-line near-infrared spectroscopy optimizing and monitoring biotransformation process of γ-aminobutyric acid. Journal of Pharmaceutical Analysis, 2016, 6: 171-178.
21. Dan Sun, Yanqi Han, Weiya Wang, Zengyong Wang, Xiaoyao Ma, Yuanyuan Hou*, Gang Bai. Screening and Identification of Caulis Sinomenii Bioactive Ingredients with Dual-target NF-κB Inhibition and ß2-AR Agonizing Activities. Biomedical Chromatography, 2016, 30(11):1843-1853.
22. Guoyu Ding, Baiqing Li, Yanqi Han, Aina Liu, Jingru Zhang, Jiamin Peng, Min Jiang, Yuanyuan Hou*, Gang Bai*. A rapid integrated bioactivity evaluation system based onnear-infrared spectroscopy for quality control of Flos Chrysanthemi. Journal of Pharmaceutical and Biomedical Analysis, 2016, 131: 391-399.
23. Jin Tao, Yan Nie, Yuanyuan Hou*, XiaoyaoMa, Guoyu Ding, Jie Gao,Min Jiang, Gang Bai*. Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Evidence-Based Complementary and Alternative Medicine, 2016, Article ID 7379146.
24. Jiajia Wang, Yan Nie, Yunjuan Li, Yuanyuan Hou*, Wei Zhao, Jiagang Deng, Peng George Wang, and Gang Bai. Identification of Target Proteins of Mangiferin in Mice with Acute Lung Injury Using Functionalized Magnetic Microspheres Based on Click Chemistry. Journal of Agricultural and Food Chemistry, 2015, 63:10013-21.
25. Runping Fang, Qingxin Cui, Jixue Sun, Xixi Duan, Xiaoyao Ma, Weiya Wang, Binfeng Cheng, Yang Liu, Yuanyuan Hou*, Gang Bai. PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin. Allergy, 2015, 70: 1622-1632.
26. Guoyu Ding, Yan Nie, Yuanyuan Hou*, Zenghui Liu, Aina Liu, Jiamin Peng, Min Jianga, Gang Bai*. An integrated strategy of marker ingredients searching and near infrared spectroscopy rapid evaluation for the quality control of Chinese eaglewood. Journal of Pharmaceutical and Biomedical Analysis, 2015, 114: 462-470.
27. Dan Sun, Mengge Zhou, Xuhui Ying, Binfeng Cheng, Yanqi Han, Yan Nie, Yuanyuan Hou* and Gang Bai. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. BMC Complementary and Alternative Medicine, 2014, 14: 356.
28. Yuanyuan Hou, Binfeng Cheng, Mengge Zhou, Runping Fang, Min Jiang, Wenbin Hou, Gang Bai*. Searching for Synergistic Bronchodilators and Novel Therapeutic Regimens for Chronic Lung Diseases from a Traditional Chinese Medicine, Qingfei Xiaoyan Wan. PLoS One, 2014, 9 (11): e113104.
29. Ya-Nan Wang1, Yuan-Yuan Hou1, Ming-Zhu Sun1, Chun-Yang Zhang, Gang Bai*, Xin Zhao*, Xi-Zeng Feng*. Behavioural screening of zebrafish using neuroactive traditional Chinese medicine prescriptions and biological targets. Scientific Reports, 2014, 4: 5311.
30. Xue Xiao, Yuanyuan Hou, Yang Liu, Yanjie Liu, Hongzhi Zhao, Linyi Dong, Jun Du, Yiming Wang, Gang Bai, Guoan Luo. Classification and analysis of corn steep liquor by UPLC/Q-TOF MS and HPLC. Talanta, 2013, 107: 344-348.
31. Cui Qingxin, Hou Yuanyuan, Hou Jie, Pan Pengwei, Bai Gang, Luo Guoan. Preparation and Optimization of Functionalized Alkynyl polyvinyl alcohol Magnetic Microspheres for the Selective Enrichment of Cell glycoproteins based on Click Chemistry. Biomacromolecules, 2013, 14(1): 124-131.
32. Yuanyuan Hou, Xuelin Cao, Linyi Dong, Liqiang Wang, Binfeng Cheng, Qian Shi, Xiaodong Luo, Gang Bai. Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris. Journal of Chromatography A, 2012, 1227: 203-209.
33. Liqiang Wang, Jiamin Peng, Binfeng Cheng, Jie Gao, Min Jiang, Gang Bai, Yuanyuan Hou*. Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats. Pharmazie, 2012, 67(2): 168-173.
34. Xiao X, Hou Y*, Du J, Liu Y, Liu Y, Dong L, Liang Q, Wang Y, Bai G, Luo G. Determination of main categories of components in corn steep liquor by near-infrared spectroscopy and partial least-squares regression. J Agric Food Chem, 2012, 60(32): 7830-7835.
35. Cheng B, Hou Y*, Wang L, Dong L, Peng J, Bai G. Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β(2)AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan. Analytical and Bioanalytical Chemistry, 2012, 404: 2445–2452.
36. Qian Shi, Yuanyuan Hou*, Jie Hou, Penwei Pan, Ze Liu, Min Jiang, Gao Jie, Gang Bai. Glycyrrhetic acid synergistically enhances β2-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. PLoS One, 2012, 7(9): e44921.
申请专利：
1. 侯媛媛，白钢，王利强，白芳，彭佳敏，朱元元，王欣，聂万达，朱晓丹（2011）延缓α-糖苷酶抑制剂吸收及增强降糖药效的口服制剂，201110148433.8
2. 白钢，侯媛媛，崔庆新，方润平，姜民，高洁（2014）一种用于治疗慢性呼吸系统疾病的药物及其制备方法，201410156796.X
3. 侯媛媛，白钢，吴文博，程传景，申福葵，姜民，高洁（2019）一种从金花茶中制备鞣花酸衍生物冲山茶苷的方法，201911154567.3
4. 侯媛媛，白钢，程传景，丛龙飞，吴文博（2019）一种金花茶叶中冲山茶苷含量的近红外快速检测方法，201911155220.0
5. 白钢，姜志宏，侯媛媛，王静荣，吴文博，唐仲尧，申福葵，张曼，姜民，高洁（2019）一种能改善细胞膜通透性的桔梗次生皂苷的制备方法，201910450176.X
6. 白钢，侯媛媛，张曼，吴文博，程传景（2020）一种可用于改善细胞膜通透性的桔梗次生皂苷682自组装纳米胶束，202010008164.4
7. 白钢，侯媛媛，汪志华（2020）一种靶向p53蛋白的寡核苷酸序列及其衍生探针和应用，202010308262.X