姓名：杨光

职称：教授，博士生导师，南开大学百名青年学科带头人

研究方向：药物化学，化学生物学，细胞生物学

电子邮件：guang.yang@nankai.edu.cn

教师简介：

杨光教授，2006年在天津大学应用化学专业获得本科学位，2009年硕士毕业于天津大学药学院药物化学专业。同年10月前往英国格拉斯哥大学（University of Glasgow）化学系攻读博士学位。导师是英国爱丁堡皇家科学院院士（FRSE），化学院院长Prof. J. Stephen Clark。2013年6月获得有机化学博士学位（Ph.D）。然后前往英国诺丁汉大学（University of Nottingham）化学系，合作导师是Dr. Robert Stockman和Prof. Christopher Moody，进行药物化学的博士后训练。期间加入了欧洲药物化学联合发展项目（European IMI），与新药研发企业（Sygnature Discovery）合作，进行新颖母核的合成探索，化合物库的制备与高通量筛选工作，服务于创新药物研发。2014年回到南开大学，进入药学院，药物化学生物学国家重点实验室，从事复杂天然产物的全合成及其相关药物化学工作。2016年7月加盟药学院，从事药物化学，化学生物学研究工作，获得多项国家自然科学基金，国际合作重大专项，国家新药创制重大专项的支持。近5年内发表SCI文章60余篇，授权专利40余项。发现多个候选药物分子并开展临床实验。

项目组主要研究方向有：

（1）基于结构与构象优化策略，针对重要靶点开展高活性的分子设计、合成、筛选与评价的研究。

（2）天然产物的全合成与半合成结构改造，发现具有重要生物活性（癌症干细胞，免疫调控，代谢调控等）的先导化合物。

（3）小分子活性探针的设计与合成，应用于先导化合物的成药靶点探索与分子机制的确认。

（4）靶向蛋白水解嵌合体（PROTAC）技术的开发及其机制的研究。

（5）手性药物合成方法学与药物分子合成工艺的开发与优化。

（6）候选药物分子的发现与创新药物分子的临床前开发。

项目组招收“药物化学”和“微生物与生化药学”专业的学生。

近年代表性论文：

1. Yubo Wang, Mengmeng Wang, Lan Ma, Yan Zhang, Yue Jiao, Shuxin Zhang, Yijie Yang, Jialu Li, Mingming Wei, Sheng Cao, Kun Zhang, Shuangwei Liu, Guang Yang^*. Identification of a potent and selective CDK9 degrader as a targeted therapeutic option for the treatment of small-cell lung cancer. J. Med. Chem. 2025, 68, 2528−2550.

2. Yubo Wang, Ruonan Wang, Yanli Zhao, Sheng Cao, Chen Li, Yanjie Wu, Lan Ma, Ying Liu, Yuhong Yao, Yue Jiao, Yukun Chen, Shuangwei Liu, Kun Zhang, Mingming Wei, Guang Yang^*. Discovery of selective and potent ATR degrader for exploration its kinase-independent functions in acute myeloid leukemia cells. Angew. Chem. Int. Ed. 2024, 63, 202318568.

3. Ziqi Huang, Kun Zhang, Yurui Jiang, Mengmeng Wang, Mei Li, Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang, Jia Chen, Jiefu Wang, Ning Liu, Xiang Liu, Shuangwei Liu, Mingming Wei, Guang Yang^*. Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Acta Pharm Sin B. 2024, 14, 4001-4013. (Cover story)

4. Yulin Liu, Liting Zheng, Ying Li, Lan Ma, Nan Zheng, Xinhua Liu, Yanli Zhao, Li Yu, Ning Liu, Shuangwei Liu, Kun Zhang, Jingfeng Zhou, Mingming Wei, Guang Yang^*. Neratinib impairs function of m6A recognition on AML1-ETO pre-mRNA and induces differentiation of t (8;21) AML cells by targeting HNRNPA3. Cancer Lett. 2024, 594, 216980.

5. Lan Ma, Kun Zhang, Ziqi Huang, Yuda Guo, Ning Liu, Jia Chen, Xinyue Wang, Ying Liu, Mei Li, Jinxiao Li, Shuangwei Liu, Guang Yang^*. Development of novel Silicon-Based Hydrophobic Tags (SiHyT) for targeted proteins degradation. J. Med. Chem. 2024, 67, 21344-21363. (Cover story)

6. Zelin Xu, Meichen Zhou, Yuer Feng, Ziyu Han, Yaoyao Li, Guang Yang, Xin Wang, Kun Zhang, Shuangwei Liu^*. Fe(iii)-triggered radical arylation of arene moieties from cyclopropanols to construct dibenzocyclohepta/octanones: synthesis of N-acetylcolchinol-O-methyl ether. Org. Lett. 2024, 26, 6950−6954. (Cover story)

7. Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, ZhaoyangWang, Yuxin Liu, Qiuying Shuai, HangWang, Peiqing Sun, Yi Shi, Guang Yang* Shuang Yang. USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer. Cancer Communications. 2023, 43, 765–787.

8. Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qing Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, Xiaoting Gu, Ting Xiao, Hui Huang, Shanshan Chen, Wen Ning, Guang Yang*, Honggang Zhou. PKM2 promotes pulmonary fibrosis by stabilizing TGF-b1 receptor I and enhancing TGF-b1 signaling. Sci. Adv. 2022, 8, eabo0987.

9. Kun Zhang, Wei Song, Mingming Wei, Yue Sun, Ning Wang, Lan Ma, Xuan Yu, Ruolin Gao, Ruonan Wang, Yan Zhang, Nan Zheng, Ning Li, Linrong Mu, Zhiwen Tang, Xuechun Li, Guang Yang* A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J. Med. Chem. 2021, 64, 15825−15845.

10. Sheng Cao, Lan Ma, Yulin Liu, Mingming Wei, Yuhong Yao, Chen Li, Ruonan Wang, Ning Liu, Zhiqiang Dong, Xuechun Li, Ming Li, Xiaoji Wang, Guang Yang* Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J. Med. Chem. 2021, 64, 16497−16511. (Cover story)

11. C. Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang, G. Yang* A robust and facile method for desulfonation to amines. Org. Chem. Front. 2021, 8, 6182. (Cover story, HOT paper)

12. Mingming Wei, Yunyun Zhou, Chong Li, Yuyu Yang, Tongtong Liu, Yulin Liu, Yujiao Wei,Ning Liu, Shuangwei Liu, Qianqian Wang, Sheng Cao, Yue Sun, Pengzhen Sheng, Cheng Lu, Xiang Liu, and Guang Yang * 5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. J. Med. Chem. 2021, 64, 12537−12547. (Cover story)

13. Yujiao Wei, Yanting Tang, Yunyun Zhou, Yuyu Yang, Yetong Cui, Xuan Wang, Yubo Wang, Yulin Liu, Ning Liu, Qianqian Wang, Chong Li, Hao Ruan, Honggang Zhou, Mingming Wei,* Guang Yang,* Discovery and Optimization of a Novel 2H‑Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor. J. Med. Chem. 2021, 64, 9078−9099.