姓名：赵炜
性别：男
职称：教授
学科方向：糖化学与糖药物学
（1）抗肿瘤糖疫苗的合成及免疫学评价；
（2）非天然核甘酸衍生物的化学合成及评价；
（3）外泌体作为药物递送系统的标记示踪与改造；
（4）脓毒症相关小分子新药的发现；
（5）抗凝血药物肝素五糖的化学改造。
招生方向： 药物化学，微生物与生化药学
通讯地址：天津市海河教育园区南开大学药学院104室
电子邮件：wzhao@nankai.edu.cn
教师简介：
赵炜，南开大学药学院副院长，教授，博导，药物化学生物学国家重点实验室课题组长。天津市131创新人才，美国化学会（ACS）会员，中国化学会高级会员，中国生物物理学会糖生物学分会副秘书长，中国化学会糖化学专业委员会委员，中国疫苗行业协会糖疫苗专业委员会委员，天津市分子药物研究重点实验室主任，《中国大百科全书》（第三版）审稿专家，有机化学博士。主持国家重点研发计划项目1项（课题负责人），国家自然科学基金3项，天津市自然科学基金4项（重点3项，面上1项），主持横向成果转化项目5项。近五年到账经费1660万元。培养博士生15人，硕士生22人。以第一或通讯作者发表SCI论文50余篇，参与撰写Elsevier英文著作一部。法国国家研究所（French National Research Agency）项目评审专家。
(1) 1995-09至1999-07, 山东大学, 学士
(2) 1999-09至2002-03, 北京科技大学, 硕士
(3) 2002-03至2005-01, 中国科学院研究生院, 博士
(4) 2005-04至2007-06, 清华大学化学系, 博士后
(5) 2009-04至2010-04, 美国俄亥俄州立大学，化学系，访问学者
科研论文目录：
30. Xue Zheng, Ke Sun, Yonghui Liu, Xiaona Yin, Haomiao Zhu*, Fan Yu*, Wei Zhao*, “Resveratrol-loaded macrophage exosomes alleviate multiple sclero sis through targeting microglia”, Journal of Controlled Release. 2023, 353, 675-684.
29. Ke Sun, Xue Zheng, Hongzhen Jin*, Fan Yu*, and Wei Zhao, “ Exosomes as CNS drug delivery tools and their applications”, Pharmaceutics. 2022, 14, 2252.
28. Hongzhen Jin, Maohua Li, Feng Tian, Fan Yu*, and Wei Zhao*, “An overview of antitumour activity of polysaccharides”, Molecules. 2022, 27, 8083.
27. Kun Wang,Tong Zhang, Mingyang Liu, Danyang Wang, Haomiao Zhu, Zhaoyu Wang, Fan Yu*, Yonghui Liu*, Wei Zhao*, “Synthesis and immunological evaluation of Mincle ligands-based antitumor vaccines”, Chinese Chemical Letters. 34, (2023), 108065.
26. Minglu Zhang, Shuo Wang, Yu Fu, Meng Meng *, Hongzhen Jin*, Wei Zhao*, “An isothiocyanate-functionalized self-immolative near-infrared fluorescence probe for cysteine sensing and bioimaging in living systems”, Sensors and Actuators: B. Chemical, 366, (2022) 132013.
25． Shuo Wang , Yueping Bai , Dayuan Wang, Yunqian Zhai, Yanqi Qiao, Xiujie Zhao, Yongmei Yin, Rimo Xi, Wei Wang, Wei Zhao*, Meng Meng*, “Reversing tumor to “Hot”: A NIR light-triggered carrier-free nanoplatform for enhanced tumor penetration and photo-induced immunotherapy”, Chemical Engineering Journal, 442, (2022) , 136322.
24. Haomiao Zhu, Kun Wang, Zhaoyu Wang, Danyang Wang, Xiaona Yin, Yonghui Liu*, Fan Yu*, and Wei Zhao*, “An efficient and safe MUC1-dendritic cell-derived exosome conjugate vaccine elicits potent cellular and humoral immunity and tumor inhibition in vivo”, Acta Biomaterialia, 2022, 138, 491–504.
23． Danyang Wang, Yonghui Liu*, Wei Zhao*, “The adjuvant effects on vaccine and the immunomodulatory mechanisms of polysaccharides from traditional Chinese medicine” , Frontiers in Molecular Biosciences, 2021, 8, 655570.
22. Yonghui Liu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin, Kun Wang, Zhangyong Hong*, Wei Zhao*, “Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine”, Chinese Chemical Letters. 32, (2021) 1963–1966.
21. Zhaoyu Wang, Qiang Chen, Haomiao Zhu, Xiaona Yin, Kun Wang, Yonghui Liu*, Wei Zhao*, “Enhancing the immune response and tumor suppression effect of antitumor vaccines adjuvanted with non-nucleotide small molecule STING agonist”, Chinese Chemical Letters. 32, (2021) 1888–1892.
20. Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, Haomiao Zhu, Kun Wang, Meng Meng*, Wei Zhao*, “The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines ”, International Journal of Nanomedicine. 2021:16 403–420.
19. Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, “ Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA ”, Journal of Controlled Release. 2021, 330, 483-492.
18. Yonghui Liu, Bocheng Yan, Zhaoyu Wang, Haomiao Zhu, Xiaona Yin, Kun Wang, Menglei Wang, and Wei Zhao*,“Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with R- and S‑FSL‑1”， ACS Med. Chem. Lett. 2020, 11, 7, 1371-1376.
17. Mingjing Li, Zhaoyu Wang, Bocheng Yan, Xiaona Yin, Yue Zhao, Fan Yu, Meng Meng, Yonghui Liu* and Wei Zhao*, “Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy”， Med. Chem. Commun, 2019, 10, 2073-2077.
16. Hongzhen Jin, Qiang Chen, Yan-Yan Zhang, Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*, “Preactivation-Based, Iterative One-Pot Synthesis of Anticoagulant Pentasaccharide Fondaparinux Sodium”， Organic Chemistry Frontiers, 2019, 6, 3116-3120.
15. Fan Yu, Song Guo, Te Li, Jie Ran, Wei Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, Xueliang Zhu, Jun Zhou*, “Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications” , Cell Research, 2019, 209 (2), 171-173.
14. Mingjing Li, Fan Yu, Chao Yao, Peng George Wang, Yonghui Liu* and Wei Zhao*, “Synthetic and immunological studies on trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates”, Organic & Biomolecular Chemistry, 2018, 16, 993 – 999.
13. Yonghui Liu, Youzhi Wang, Fan Yu, Zhenqing Zhang, Zhimou Yang, Wenpeng Zhang,* Peng George Wang and Wei Zhao *, “Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant”. Chemical Communications, 2017, 53, 9486-9489.
12. Guoqiang Zhang, Hongzhen Jin, Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, Peng George Wang, Hao Gan, * Huifei Cui, * Wei Zhao*, An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17, European Journal of Medicinal Chemistry, 2017, 126, 1039-1055.
11. Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang* and Wei Zhao*, “Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.
10. Lei Li, Yonghui Liu, Tiehai Li, Wenjun Wang, Zaikuan Yu, Cheng Ma, Jingyao Qu, Wei Zhao, Xi Chen and Peng G. Wang*, “Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms”, Chem. Commun, 2015,51, 10310-10313.
9. Yun Xu, Wenjun Wang, Yu Cai, Xia Yang,
Peng George Wang and Wei Zhao*, “A convenient and efficient synthesis of glycals by
zinc nanoparticles”, RSC Advances, 2014, 4 , 46662 - 46665.
8. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic &
Biomolecular Chemistry, 2014, 12, 7310–7317.
7. Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, and Peng Wang*, “Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.
6. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao*, and Peng George Wang*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.
5. Lina Guo, Yonghui Liu, Yue Wan, Peng George Wang and Wei Zhao*, “Effective and one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanes for the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54，2579-2582.
4. Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang*, Wei Zhao*, “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & Medicinal Chemistry Letters. 22 (2012) 6854-6857.
3. Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*, and Peng Wang*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012, 355C, 34-38.
2. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*, “Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in Medicinal Chemistry. 2012, 12, 1533-1541.
1. Wenjun Wang,Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang*, Lei Li*, Wei Zhao*, and Peng George Wang, “Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242.