姓名：赵炜
性别：男
职称：教授
学科方向：糖化学与糖药物学
（1）抗肿瘤糖疫苗的合成及免疫学评价；
（2）非天然核甘酸衍生物的化学合成及评价；
（3）外泌体作为药物递送系统的标记示踪与改造；
（4）脓毒症相关小分子新药的发现；
（5）抗凝血药物肝素五糖的化学改造。
招生方向： 药物化学，微生物与生化药学
通讯地址：天津市海河教育园区南开大学药学院104室
电子邮件：wzhao@nankai.edu.cn
教师简介：
赵炜，南开大学药学院副院长，教授，博导，药物化学生物学国家重点实验室课题组长。天津市131创新人才，美国化学会（ACS）会员，中国化学会高级会员，中国生物物理学会糖生物学分会副秘书长，中国化学会糖化学专业委员会委员，中国疫苗行业协会糖疫苗专业委员会委员，天津市分子药物研究重点实验室主任，《中国大百科全书》（第三版）审稿专家，有机化学博士。主持国家重点研发计划项目1项（课题负责人），国家自然科学基金3项，天津市自然科学基金4项（重点3项，面上1项），主持横向成果转化项目5项。近五年到账经费1660万元。培养博士生15人，硕士生22人。以第一或通讯作者发表SCI论文50余篇，参与撰写Elsevier英文著作一部。法国国家研究所（French National Research Agency）项目评审专家。
(1) 1995-09至1999-07, 山东大学, 学士
(2) 1999-09至2002-03, 北京科技大学, 硕士
(3) 2002-03至2005-01, 中国科学院研究生院, 博士
(4) 2005-04至2007-06, 清华大学化学系, 博士后
(5) 2009-04至2010-04, 美国俄亥俄州立大学，化学系，访问学者
科研论文目录：
18．Danyang Wang, Kaixuan Wang, Hongzhen Jin*, Wei Zhao*, and Fan Yu*, “A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm”, Advanced Science. 2024, 2403337.
17. Minglu Zhang, Shuo Wang, Yueping Bai, Bing Wang*, Hongzhen Jin*, Wei Zhao*, “A Dual-function Hemicyanine material with highly efficient photothermal and photodynamic effect used for tumor therapy”, Advanced Healthcare Materials, 2023, 2303432.
16. Xue Zheng, Yujie Xing, Ke Sun, Hongzhen Jin*, Wei Zhao*, Fan Yu*，“Combination therapy with resveratrol and celastrol using folic acid-functionalized exosomes enhances the therapeutic efficacy of sepsis”，Advanced Healthcare Materials, 2023, 2301325.
15. Xue Zheng, Ke Sun, Yonghui Liu, Xiaona Yin, Haomiao Zhu*, Fan Yu*, Wei Zhao*, “Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia”, Journal of Controlled Release. 2023, 353, 675-684.
14. Kun Wang,Tong Zhang, Mingyang Liu, Danyang Wang, Haomiao Zhu, Zhaoyu Wang, Fan Yu*, Yonghui Liu*, Wei Zhao*, “Synthesis and immunological evaluation of Mincle ligands-based antitumor vaccines”, Chinese Chemical Letters. 34, (2023), 108065.
13. Minglu Zhang, Shuo Wang, Yu Fu, Meng Meng *, Hongzhen Jin*, Wei Zhao*, “An isothiocyanate-functionalized self-immolative near-infrared fluorescence probe for cysteine sensing and bioimaging in living systems”, Sensors and Actuators: B. Chemical, 366, (2022) 132013.
12． Shuo Wang, Yueping Bai, Dayuan Wang, Yunqian Zhai, Yanqi Qiao, Xiujie Zhao, Yongmei Yin, Rimo Xi, Wei Wang, Wei Zhao*, Meng Meng*, “Reversing tumor to “Hot”: A NIR light-triggered carrier-free nanoplatform for enhanced tumor penetration and photo-induced immunotherapy”, Chemical Engineering Journal, 442, (2022), 136322.
11. Haomiao Zhu, Kun Wang, Zhaoyu Wang, Danyang Wang, Xiaona Yin, Yonghui Liu*, Fan Yu*, and Wei Zhao*, “An efficient and safe MUC1-dendritic cell-derived exosome conjugate vaccine elicits potent cellular and humoral immunity and tumor inhibition in vivo”, Acta Biomaterialia, 2022, 138, 491–504.
10． Danyang Wang, Yonghui Liu*, Wei Zhao*, “The adjuvant effects on vaccine and the immunomodulatory mechanisms of polysaccharides from traditional Chinese medicine”, Frontiers in Molecular Biosciences, 2021, 8, 655570.
9. Yonghui Liu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin, Kun Wang, Zhangyong Hong*, Wei Zhao*, “Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine”, Chinese Chemical Letters. 32, (2021) 1963–1966.
8. Zhaoyu Wang, Qiang Chen, Haomiao Zhu, Xiaona Yin, Kun Wang, Yonghui Liu*, Wei Zhao*, “Enhancing the immune response and tumor suppression effect of antitumor vaccines adjuvanted with non-nucleotide small molecule STING agonist”, Chinese Chemical Letters. 32, (2021) 1888–1892.
7. Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, Haomiao Zhu, Kun Wang, Meng Meng*, Wei Zhao*, “The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines”, International Journal of Nanomedicine. 2021:16 403–420.
6． Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, “Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA”, Journal of Controlled Release. 2021, 330, 483-492.
5. Mingjing Li, Zhaoyu Wang, Bocheng Yan, Xiaona Yin, Yue Zhao, Fan Yu, Meng Meng, Yonghui Liu* and Wei Zhao*, “Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy”, Med. Chem. Commun, 2019, 10, 2073-2077.
4. Hongzhen Jin, Qiang Chen, Yan-Yan Zhang, Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*, “Preactivation-Based, Iterative One-Pot Synthesis of Anticoagulant Pentasaccharide Fondaparinux Sodium”, Organic Chemistry Frontiers, 2019, 6, 3116-3120.
3. Mingjing Li, Fan Yu, Chao Yao, Peng George Wang, Yonghui Liu* and Wei Zhao*, “Synthetic and immunological studies on trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates”, Organic & Biomolecular Chemistry, 2018, 16, 993 – 999.
2. Yonghui Liu, Youzhi Wang, Fan Yu, Zhenqing Zhang, Zhimou Yang, Wenpeng Zhang*, Peng George Wang and Wei Zhao *, “Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant”. Chemical Communications, 2017, 53, 9486-9489.
1. Guoqiang Zhang, Hongzhen Jin, Hao Gan, * Huifei Cui, * Wei Zhao*, “An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17”. European Journal of Medicinal Chemistry, 2017, 126, 1039-1055.