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郭宇

姓名:郭宇

职称:副教授

学科方向:结构生物学、化学生物学、病毒学与抗病毒药物开发。

招生方向:生物化学与分子生物学

通讯地址:南开大学药学院天津市海河教育园区同砚路38号,300350

电话:022-65378882

传真:022-65378882

电子邮件:guoyu@nankai.edu.cn

教师简介:

    2007年本科毕业于南开大学生命科学学院,2007至2010年期间在清华大学医学院学习,2012年毕业于南开大学生命科学学院,获理学博士学位;2012年7月加入南开大学药学院工作,2015年晋升为副教授。主要研究方向为利用生物大分子结构生物学的研究方法,探求重大传染性疾病的致病机理与结构基础,并据此进行创新药物的开发。主持承担国家自然科学基金面上与青年项目、天津市及教育部自然科学基金等课题,参与了国家重点基础研究发展计划,国际合作计划等项目,在Proc Natl Acad Sci USA,J Virol, ANTIMICROB AGENTS CH等国际期刊上发表研究论文30余篇。

代表性论文:

1. Guo Yu,Wang Yaxin ,Cao Lin,Wang Peng,Qing Jie,ZhengQizhen,Shang Luqing,Yin Zheng,Sun Yuna,A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus.,Antimicrob Agents Chemother,2015,60(2):913-924.

2. Guo Yu,Wang Wenming,Sun Yuna,Ma Chao,Wang Xu,Wang Xin,Liu Pi,Shen Shu,Li Baobin,Lin Jianping,Deng Fei,Wang Hualin,Lou Zhiyong,Crystal structure of the core region of hantavirus nucleocapsid protein reveals the mechanism for ribonucleoprotein complex formation.,Journal of Virology,2015,90(2):1048-1061.

3. Wang Wenming,Liu Xiang ,Wang Xu,DongHui,Ma Chao,Wang Jingmin,Liu Baocheng,Mao Yonghong,Wang Ying,Li Ting,Yang Cheng,Guo Yu,Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins,Journal of Virology,2015,89(23):11740-11749.

4. Dong Shishang,Yang Peng,Li Guobang,Liu Baocheng,WangWenming,Liu Xiang,Xia Boran,Yang Cheng,Lou Zhiyong,Guo Yu,Rao Zihe,Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 A resolution.,Protein & Cell,2015,6(5):351-362.

5. Sun Yuna,Guo Yu,Lou Zhiyong ,Formation and working mechanism of the picornavirus VPg uridylylation complex.,Curr Opin Virol,2014,9:24-30.

6.  Li Ningning,Xu Yintong,Xia Qiang,Bai Cuigai,Wang Taiyi,Wang Lei,He Dingdi,Xie Nannan,Li Lixin,Wang Jing,Zhou Hong-Gang,Xu Feng,Yang Cheng,Zhang Quan,Yin Zheng,Guo Yu,Chen Yue*,Simplified captopril analogues as NDM-1 inhibitors,Bioorganic & Medicinal Chemistry Letters,2014,24(1):386-389.

7.  Zhou Honggang,Sun Yuna,Wang Ying,Liu Min,Liu Chao,Wang Wenming,Liu Xiang,Li Le,Deng Fei,Wang Hualin,Guo Yu,Lou Zhiyong*,The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation.,Protein &Cell,2013,4(6):445-455.

8. Guo Yu,Wang Wenming,Ji Wei,Deng Maping,Sun Yuna,Zhou Honggang,Yang Cheng,Deng Fei,Wang Hualin,Hu Zhihong,Lou Zhiyong,Rao Zihe,Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses.,Proceedings of the National Academy of Sciences of the United States of America,2012,109(13):5046-5051.

9. GuoYu,Wang Jing,Niu Guojun,Shui Wenqing,Sun Yuna,Zhou Honggang,Zhang Yaozhou,Yang Cheng,Lou Zhiyong,Rao Zihe,A structural view of the antibiotic degradation enzyme NDM-1 from a superbug.,Protein &Cell,2011,2(5):384-394.



    • 联系人:药学院办公室

    • 邮箱:yaoxueyuan@nankai.edu.cn

    • 电话: 86-22-23506290

    • 地址:天津市海河教育园区同砚路38号        版权所有  南开大学药学院        访问量 155707