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卢亚欣

姓名: 卢亚欣

职称: 副教授

学科方向: 药剂学

研究方向: 药物动力学与生物分析

通讯地址:天津津南区海河教育园区同砚路38号, 300353

电子邮件:yaxinlu @nankai.edu.cn

教师简介:

卢亚欣,女,1980年生,副教授,硕士生导师。2007年获沈阳药科大学药剂学专业博士学位,毕业后来到南开大学工作。讲授本科生《药剂学》、《药学概论》等课程,主要研究方向是药物动力学及生物分析,利用在线固相萃取及生物质谱等生物分析手段,研究药物动力学、药物代谢及药物作用机理的探索。已完成参与研发的1.1类新药其临床前药动学申报资料,并通过天津市药监局考核,目前该新药已在澳大利亚开展临床试验。

卢亚欣副教授已主持天津市自然基金项目1项,中央高校基金科研业务费1项,及横向课题三项。主持校教学改革项目共4项,参与天津市教学改革重点项目1项。参与南开大学新专业课程建设项目4项,获校教学成果奖2等奖1项(第一完成人)。2009年至今负责本科生毕业论文的管理工作,5次获得校本科教学质量管理工作优秀奖。指导本科生创新科研“百项工程”项目共3项,获得校级2等奖1项,3等奖1项。指导的本科生毕业设计1项获得南开大学优秀毕业论文。已发表论文10余篇。

代表性论文:

1. Man Wang, Ping Ma, Xiaonan Xi, Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Yaxin Lu*, Zheng Yin*, Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma. Talanta, 2016, 161: 278-287.

2. Zhihong Wang1, Yaxin Lu1, Kang Qin, YifanWu, Yingping Tian, JianingWang, Jimin Zhang, Jingli Hou, Yun Cui, KaiWang, Jie Shen, Qingbo Xu, Deling Kong, Qiang Zhao*, Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug. J. Control. Release, 2015, 210: 179-188.

3.  Ping Li, Yiran Fan, Yunlong Wang, Yaxin Lu*, Zheng Yin*, Characterization of plasma protein binding dissociation with online SPE-HPLC. Scientific Reports, 2015, 5, 14866.

4. Yiran Fan, Guanghu Shen, Ping Li, Xiaonan Xi, Haiting Wu, Hongjun Tian, Yaxin Lu*, Zheng Yin*, A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring. RSC Adv. 2015, 5: 34342–34352.

5. Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Yaxin Lu*, Zheng Yin*, Simultaneous determination of a broad range of cardiovascular drugs in plasma with a simple and efficient extraction/clean up procedure and chromatography– mass spectrometry analysis. RSC Adv. 2014, 4: 19629–19639.

6. Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Meng Wu, Guifang Han, Yaxin Lu*, Qingming Wang*, Zheng Yin*. Optimization of on-line solid phase extraction and HPLC conditions using response surface methodology for determination of WM-5 in mouse plasma and its application to pharmacokinetic study. J Chromatogr B, 2013, 923-924: 8-15.

7. Quan Zhang1, Yaxin Lu1, Yahui Ding1, Jiadai Zhai1, Qing Ji, Weiwei Ma, Ming Yang, Hongxia Fan, Jing Long, Bin Han, Wenpeng Zhang, Chuanjiang Qiu, Xiaoyan Ma, Zhongsheng Tong, Yehui Shi, Yongsheng Jia, Qianqian Shi, Haoliang Zhang, Dongmei Li, Jing Zhang, Jianping Lin, Lu-Yuan Li, Yingdai Gao*, Yue Chen*. Guaianolide Sesquiterpene Lactones, a Source to Discover Agents That Selectively Ablate Acute Myelogenous Leukemia Stem and Progenitor Cells. J. Med. Chem. 2012, 55, 8757?8769.

8.Lei Liu, Kangning Liu, Yabin Wen, Hanwen Zhang , Ya-Xin Lu*, Zheng Yin*. Development of a fully automated on-line solid phase extraction and high-performance liquid chromatography with diode array detection method for the pharmacokinetic evaluation of bavachinin: a study on absolute bioavailability and dose proportionality. J Chromatogr B. 2012, 893-894: 21-28.

申请专利:

1.陈悦,张泉,卢亚欣,丁亚辉,翟佳黛,马维维,范洪霞,张浩亮,王淼. 中国专利:含笑内酯及其衍生物用于治疗癌症的用途,申请号:201010510726.1(2010)(已授权,授权公告日号:CN 101978959 B,授权公告日 2012.08.15).

2.陈悦,张泉,卢亚欣,翟佳黛,马维维,丁亚辉,范洪霞,张浩亮,王淼. 中国专利:含笑内酯及其衍生物用于治疗丙型肝炎的用途,申请号:201010510940.7(2010)(已授权,授权公告日号:CN 101966176 B,授权公告日 2012.07.04).


    • 联系人:药学院办公室

    • 邮箱:yaoxueyuan@nankai.edu.cn

    • 电话: 86-22-23506290

    • 地址:天津市海河教育园区同砚路38号        版权所有  南开大学药学院        访问量 155707