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杨雪

姓名:杨雪

职称:副研究员

学科方向:钙离子信号转导;结构生物学

招生方向:微生物与生化药学

通讯地址:天津市津南区南开大学新校区 综合实验楼D214

电话:022-85358251

电子邮件: yangxue@nankai.edu.cn

教师简介:

2002年至2006年,就读于中国农业大学,获学士学位;

2007年至2012年,就读于南开大学生命科学学院生物化学与分子生物学专业,获博士学位;2012年7月至2014年12月  南开大学药物化学生物学国家重点实验室担任助理研究员;

2014年12月至今 南开大学药物化学生物学国家重点实验室担任副研究员。

主要研究方向是钙离子信号相关蛋白的三维结构解析与功能调控的分子机理探讨。目前承担国家自然科学基金青年基金1项。天津市应用基础与前沿技术研究计划青年项目1项,参与国家重点基础研究发展计划(973计划)子课题两项。以第一作者及通讯作者身份在PNAS、EMBO J、FASEB J.、Nucleic Acids Res.、Acta Crystallogr. Sect. D,PLoS One、J. Struct. Biol.等国际期刊发表研究性论文十余篇。

代表性论文:

1. Li L, Xing Y, Chang D, Fang S, Cui B, Li Q, Wang X, Guo S, Yang X*, Men S*, Shen Y*. CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence. Sci Rep. 2016 Aug 19;6:31889

2. Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X*, Cong Y*, Shen Y*. Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2 /H  antiporter. Sci Rep. 2016 Sep 27;6:34174.

3. Wang L, Yang X (co-first author), Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y*  Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 2014 Mar 18;33(6):594-604.

4. Wang Z, Yang X (co-first author), Guo S, Yang Y, Su X, Shen Y*, Long J* Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J. Bio. Chem. 2014 Aug; 289(40).

5. Cui B, Yang X (co-first author), Li S, Lin Z, Wang Z, Dong C, Shen Y.* The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. PLoS One. 2013 Sep 19;8(9)

6. Fang S, Li L, Cui B, Men S, Shen Y, Yang X.* Structural insi ht into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr. D Biol. Crystallogr. 2013 Jun;69(Pt 6):934-45

7. Dong C, Yang X (co-first author), Hou HF, Shen YQ*, Dong YH*  Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9)

8. Wang Z., Yang X (co-first author), Chu X., Zhang J., Zhou H., Shen Y.*, Long J.*. The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res. 2012 May; 40(9), 4193-202.

9. Yang X., Jin H., Cai X., Li S., Shen Y.*  Structural and Mechanistic Insights into the Activation of STIM1, Proc. Nati. Acad. Sci. USA, 2012 April; 109(15), 5657–5662.

10. Li FZ., Li SW., Wang Z., Shen YQ, Zhang TC.*, Yang X.*  Structure of the kinase domain of human RNA-dependent protein kinase with K296R mutation reveals a face-to-face dimer. Chinese Sci. Bull. 2013 Vol. 58 (9): 998-1002

11. Zhang J., Yang X., Wang Z., Shen Y.* Long J.* (2012) Structure of an L27 domain heterotrimer from the cell polarity complex Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly mode., J. Biol. Chem. 2012 Feb; 68 (Pt2): 95-101

12. Dong C., Hou H., Yang X., Shen Y., Dong Y.*. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly. Acta Crystallogr. D Biol. Crystallogr. 2012 Feb;68 (Pt 2):95-101.

13. Zhang J., Yang X.*, Shen Y., Long J. Crystallization and preliminary X-ray data collection of the L27PATJ–(L27N,L27C)Pals1–L27MALS tripartite complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.2011 Nov 1;67(Pt 11):1443-7 

14. Wang X., Yang X., Yang C., Wu Z., Xu H.*, Shen Y.* Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. PLoS One. 2011 Oct;6(10): e26845.

15. Qin X., Ren L., Yang X., Bai F., Wang L., Geng P., Bai G.*, Shen Y.* Structures of human pancreatic α-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.. J. Struct. Biol. 2011 Apr; 174(1): 196-202.

16. Yang X., Xie X., Chen L., Zhou H., Wang Z., Zhao W, Tian R, Zhang R, Tian C, Long J*, Shen Y*.  Structural basis for tandem L27 domain-mediated polymerization. FASEB J. 2010 Dec; 24(12): 4806-15.

17. Qin X., Sun L., Wen X., Yang X., Tan Y., Jin H., Cao Q., Zhou W., Xi Z., Shen Y.*.  Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis. J. Struct. Biol. 2010 Apr; 170(1):76-82.

18. Yang, X., Wu, Z., Wang, X., Yang C., Xu, H.*, Shen, Y.* Crystal structure of lipoprotein GNA1946 from Neisseria meningitides. J.Struct.Biol., 2009 Dec; 168, 437-443.

19. Zhang J., Yan X., Shi C., Yang X., Guo Y., Tian C., Long J., Shen Y.* Structural basis of b-catenin recognition by Tax-interacting protein-1, J. Mol. Biol. 2008 Dec 5;384(1):255-63

 (* Corresponding author)


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