师资队伍教授
林建平

姓名:林建平

职称:教授

学科方向:计算生物学

招生方向:药物化学

课题组成员

副教授:李冬梅

通讯地址:天津市海河教育园区同砚路38号南开大学药学院,邮编300353

传真:022-23507760

电子邮件:jianpinglin@nankai.edu.cn

教育背景与工作经历

1997年和2000年先后在北京大学化学院获得学士和硕士学位。2005年7月毕业于美国杜克大学,获得理论生物物理和化学博士学位。2006年在美国希望之城医学中心从事博士后工作。2009年作为引进人才,回国到南开大学工作。

研究方向:计算机辅助药物设计,生物大分子模拟,蛋白质电子转移。

通过分子动力学和虚拟化合物库计算机筛选以及实验组合作, 我们找到一个针对癌症增生蛋白(信号传送和转录激活因子,Signal transducers and Activators of Transcription 3 (Stat3))的抑制剂, 从而阻断癌症增生通道.这个抑制剂是第一个对Stat3有选择性的抗癌药.通过计算机辅助设计和分子动力学验证, 设计出憎水性的脱氧核糖核酸(DNA).设计出的憎水性DNA能穿过水和氯仿界面进入氯仿相。

林建平先后承担国家自然科学基金面上项目1项、973子课题1项。

林建平讲授的课程研究生必修课《计算机辅助药物设计》。

代表性论文:

1.  Hengkai Meng, Pi Liu, Hongbing Sun, Zhen Cai, Jie Zhou*, Jianping Lin*, Yin Li*, Engineering a D-lactate dehydrogenase that can superefficiently utilize NADPH and NADH as cofactors, Sci. Rep. 2016, 6: 24887.

2. Zhonghua Wang, Lu Liang, Zheng Yin, Jianping Lin*, Improving chemical similarity ensemble approach in target prediction, J. Cheminf. 2016, 8: 20.

3. Yang Li, Jixue Sun, Dongmei Li*, Jianping Lin*, Activation and conformational dynamics of a classB G-protein-coupled glucagon receptor, Phys. Chem. Chem. Phys. 2016, 18: 12642-12650.

4. Wei, Yu, Jinlong Li, Jie Qing, Mingjie Huang, Ming Wu, Fenghua Gao, Dongmei Li, Zhangyong Hong, Lingbao Kong*, Weiqiang Huang*, Jianping Lin*, Discovery of novel hepatitis C virus NS5B polymerase inhibitors by combining random forest, multiple e-pharmacophore modeling and docking, PLoS ONE 2016, 11: e0148181.

5. Qiaoyun Guo, Yu Wei, Bin Xia, Yongxin Jin, Chang Liu, Xiaolei Pan, Jing Shi, Feng Zhu, Jinlong Li, Lei Qian, Xinqi Liu, Zhihui Cheng, Shouguang Jin*, Jianping Lin*, Weihui Wu*, Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa, Sci. Rep. 2015, 6: 19141.

6. Han, Li, Pi Liu, Jixue Sun, Yuanqing Wu, Yuanyuan Zhang, Wujiu Chen, Jianping Lin*, Qinhong Wang*, Yanhe Ma, Engineering catechol 1, 2-cioxygenase by cesign for improving the performance of the cis, cis-muconic acid synthetic pathway in escherichia coli, Sci. Rep. 2015, 5: 13435.

7. Pi Liu, Zhonghua Wang, Lijie Zhang, Dongmei Li*, Jianping Lin*, The mechanism by which 146-N-glycan affects the active site of neuraminidase, PLoS ONE 2015, 10: e0135487.

8. Wei, Yu, Jinlong Li, Zeming Chen, Fengwei Wang, Weiqiang Huang*, Zhangyong Hong*, Jianping Lin*, Multistage virtual screening and identification of novel HIV-1 protease inhibitors by integrating SVM, shape, pharmacophore and docking methods, Eur. J. Med. Chem. 2015, 101: 409-418.

9. Junli Xu, Zhonghua Wang, Pi Liu*, Dongmei Li*, Jianping Lin*, An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1, Mol. BioSyst. 2015, 11, 2042-2050.

10. Huo, Tong, Wei Liu, Yu Guo, Cheng Yang, Jianping Lin*, Zihe Rao. Prediction of host-pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs, BMC Bioinform. 2015, 16: 100.

11. Zhonghua Wang, J. Li, Ruoyu Dang, Lu Liang, Jianping Lin, PhIN: A protein pharmacology interaction network database, CPT Pharmacometrics Syst. Pharmacol. 2015, 4: 160–166.

12. Dongmei Li*, Cui Liu, Jianping Lin*, Theoretical study of the mechanism of protein arginine deiminase 4 (PAD4) inhibition by F-amidine, J. Mol. Graph. Model. 2015, 55, 25-32.

13. Zhihui Yan, Lijie Zhang, Haiyang Fu, Zhonghua Wang, Jianping Lin*, Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking, Bioorg. Med. Chem. Lett. 2014, 24: 539-547.

14. Li Han, Pi Liu, Y. Peng, Jianpign Lin*, Qinhong Wang* Yanhe Ma, Engineering the biosynthesis of novel rhamnolipids in Escherichia coli for enhanced oil recovery, J. Appl. Microbio. 2014, 117: 139-150.

15. Feng Sang, Peng Feng, Jie Chen, Yahui Ding, Xiyan Duan, Jiadai Zhai, Xiaoyan Ma, Bin Zhang, Quan Zhang, Jianping Lin*, Yue Chen*, Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities, Eur. J. Med. Chem. 2013, 68: 321-332.

16. Huo, Tong, Yinjie Zhang, Jianping Lin*. Functional annotation from the genome sequence of the giant panda.” Protein Cell 2012, 3: 602-608.

17. Jianping Lin*, Pi Liu, Hua-Zheng Yang, Vaidehi Nagarajan*, Factors that affect the computational prediction of hot spots in protein-protein complexes, Comput. Mol. Biosci. 2012, 2: 23-34.

18. Jianping Lin, Ralf Buettner, Yate-Ching Yuan, Richard Yip, David Horne, Richard Jove, Nagerajan Vaidehi*, Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3, J. Mole. Graphics Model. 2009, 28: 347-356.

19. Jianping Lin, Nadrian C. Seeman, Nagarajan Vaidehi*, Molecular dynamics simulations of insertion of chemically modified DNA nanostructures into water-chloroform interface, Biophys. J. 2008, 95: 1099-1107.

20. Jianping Lin, Ilya A. Balabin, David N. Beratan*, The nature of aqueous tunneling pathways between electron-transfer proteins” Science 2005, 310: 1311-1313. Related news: “Water can ease electron transfer between proteins” Chemical & Engineering News, November 28, 2005, Page 11.

21. Jianping Lin, David N. Beratan*, Simulation of electron transfer between cytochrome c2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants, J. Phys. Chem. B 2005, 109: 7529-7534.

22. Jianping Lin, David N. Beratan*, Tunneling while pulling: The dependence of tunneling current on end-to-end distance in a flexible molecule, J. Phys. Chem. A 2004, 108: 5655-5661.

23. James C. Sung, Jianping Lin. Diamond Nanotechnology: Synthesis and applications, Pan Stanford Publishing, 2009.

24. Spiros S. Skourtis, Jianping Lin; David N. Beratan. The Effects of Bridge Motion on Electron Transfer Reactions Mediated by Tunneling, Chapter 18 in Modern Methods for Theoretical Physical Chemistry of Biopolymers. Edited By E. B. Starikov; S. Tanaka; J. P. Lewis, Elsevier Press, June 2006.