师资队伍教授
赵炜

姓名:赵炜

职称:教授

学科方向:药物化学

研究方向:糖化学与化学生物学

通讯地址:天津市海河教育园区南开大学药学院109室

电子邮件:wzhao@nankai.edu.cn

教师简介:

南开大学药学院教授,副院长,有机化学博士。1999年7月毕业于山东大学化学系,获学士学位;2005年4月毕业于中国科学院研究生院,获理学博士学位(师承孔繁祚研究员)。 2005年3月进入清华大学化学系从事博士后研究工作,师从李艳梅教授,从事糖肽的合成及免疫学性质研究。2007年6月加入南开大学药学院。2009-2010年在美国俄亥俄州立大学化学与生物化学系作访问学者,并在美国国立卫生院(NIH)Frederick分部做短期交流访问。主持或参加多项国家自然科学基金重点及面上课题和科技部973课题的研究,多年从事糖化学和化学生物学领域的科研,研究方向为肿瘤相关糖肽疫苗和肝素类抗血栓药物的设计合成与生物学评价。

代表性论文:

1.  Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang and Wei Zhao*, “Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.

2.     Yonghui Liu, Tianbang Song, Weijia Meng, Yun Xu, Peng George Wang, Wei Zhao*,“Hafnium(IV) triflate as a highly efficient catalyst for Ferrier rearrangement of O- and S-nucleophiles with glycals”, Tetrahedron Letters. 2016, 25,2758–2762.

3.  Jiajia Wang, Xiaomin Wang, Yunyan Zhao, Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, Peng George Wang and Wei Zhao*,“Synthesis and biological evaluation of D-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease”, Med. Chem. Commun, 2016, 7, 365.

4. Wenjun Wang, Zhongyue Yang, Yun Xu, Taibao Liu, Tianbang Song, Yunyan Zhao, Xiufang Xu*, Wei Zhao* and Peng George Wang*, ““Armed and disarmed” theory in the addition of an azide radical to glucals”, RSC Advances, 2015, 5, 38577 - 38580.

5. Yun Xu, Wenjun Wang, Yu Cai, Xia Yang,Peng George Wang and Wei Zhao*, “A convenient and efficient synthesis of glycals byzinc nanoparticles”, RSC Advances, 2014, 4 , 46662 - 46665.

6. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic & Biomolecular Chemistry, 2014, 12, 7310–7317.

7. Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, and Peng Wang*, “Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.

8. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao*, and Peng George Wang*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.

9. Lina Guo, Yonghui Liu, Yue Wan, Peng George Wang and Wei Zhao*,“Effective and one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanes for the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54,2579-2582.

10. Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang*, Wei Zhao*, “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & Medicinal Chemistry Letters. 22 (2012) 6854-6857.

11. Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*, and Peng Wang*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012, 355C, 34-38.

12. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*,“Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in Medicinal Chemistry. 2012, 12, 1533-1541. 

13. Wenjun Wang, Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang, Lei Li, Wei Zhao*, Peng George Wang*,“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242. 

14. Wenjun Wang, Lei Li, Chen Jin, Yujie Niu, Sen Li, Ji Ma, Linfeng Li, Yu Liu, Li Cai, Wei Zhao*, Peng George Wang*,“Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support.” Bioorganic & Medicinal Chemistry Letters. 2011, 17, 5041-5044.

15. Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang , Lei Li, Jianping Lin, Wei Zhao*, Jing Li*and Peng George Wang*, “Design and synthesis of O-GlcNAcase inhibitors via Click Chemistry and biological evaluations.”Carbohydrate Research. 346 (2011) 1083-1092.

16. Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao* and Peng George Wang* , “Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136-2144.

出版著作:

 Enzymatic Synthesis of Complex Carbohydrates. Comprehensive Natural Products Chemistry II. Volume 6. Elsevier 2010, 5-54.