师资队伍教授
帅领

姓名:帅领,博士生导师

职称:特聘研究员

学科方向:药物靶标的疾病分子机制研究

研究方向:干细胞与遗传学

通讯地址:天津市津南区同砚路38号,南开大学综合实验楼D420;

邮编:300350;

电话:022-85358245;

电子邮箱: lshuai_nk@163.com


教师简介

帅领研究员,男,1986年生。药物化学生物学国家重点实验室研究员。系东北农业大学八年制“本硕博”连读理科基地班优秀毕业生,于2013年获理学博士学位。帅领博士毕业后,师从中国科学院动物研究所周琪院士从事博士后研究工作,并于2015年11月加入药物化学生物学国家重点实验室任特聘研究员。同年,帅领研究员入选“天津市优秀国际博士后计划”,出访瑞士联邦理工学院生命健康分子所任访问科学家(2016年3月至6月)。帅领研究员主要从事细胞重编程和基因筛选相关领域的研究。近5年已发表SCI科技论文12篇,其中包括第一作者身份6篇,参与作者6篇,其代表性作《Androgenetic haploid embryonic stem cells produce live transgenic mice》刊登于世界顶级期刊《Nature》,并被科技部评选为“2012年中国科学十大进展”。该研究在世界范围内,首次实现了利用基因修饰的单倍体胚胎干细胞获得健康成活的转基因哺乳动物。帅领研究员目前主持国家自然科学基金项目2项,天津市自然科学基金重点项目1项。


代表性论文:

1. Li W#, Shuai L#, Wan HF#, Dong MZ#, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang LB, Zheng QY, Sheng C, Wu HJ, Liu ZH, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420) (2012):407-411.(#: Equal contribution)

2. Liu ZC#, Wan HF#, Wang EY#, Zhao XY, Ding CH, Zhou SY, Li TQ, Shuai L, Feng CJ, Yu Y, Zhou Q*, Beaujean N*. Induced pluripotent stem induced cells show better constitutive heterochromatin remodeling and developmental potential after nuclear transfer than their parental cells. Stem Cell Development 21(16) (2012):3001-3009.

3. Shuai L#, Feng CJ#, Zhang HJ#, Gu Q, Jia YD, Wang L, Zhao XY, Liu ZH*, Zhou Q*. Derivation of androgenetic embryonic stem cells from m-carboxycinnamic acid bishydroxamide (CBHA) treated androgenetic embryos. Chinese Science Bulletin 58(23) (2013):2862-2868.

4. Wan HF#, He ZQ#, Dong MZ, Gu TT, Luo GZ, Teng F, Xia BL, Li W, Feng CJ, Li X, Li TD, Shuai L, FuR, Wang L, WangXJ, Zhao XY* and Zhou Q*. Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell research 23(2013):1330-1333.

5. Shuai L, Zhou Q*. Haploid embryonic stem cells serve as a new tool for mammalian genetic study. Stem Cell Research & Therapy 5(1) (2014):20.

6. Li W#, Li X#, Li TD#, Jiang MG#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in the rat using haploid embryonic stem cells. Cell Stem Cell 14(3) (2014):404-414.

7. Shuai L., Li W, Wan H, Zhao XY, Wang L, Zhou Q. Generation of Mammalian Offspring by Haploid Embryonic Stem Cells Microinjection. Curr. Protoc. Stem Cell Biol. 31(2014):1A.6.1–1A.6.15.

8. Shuai L#, Wang Y#, Dong M#, Wang X#, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q*. 2015 Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. Journal of Molecular Cell Biology 7(4) (2015):326-337.

9. Li X#, Wang JQ#, Wang LY#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. Journal of Molecular Cell Biology 7(5) (2015):486-488.

10. Li X#, Cui XL#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Wang XJ, Liu ZH, Li W*, Zhou Q*. Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells. Cell 164(1-2) (2016):279-292.

11. Li.T.D.#, Shuai.L.#, Mao.J.J.#, Wang. X.P., Wang.M., Zhang X.X., Wang.L., Li.Y.N., Li.W., Zhou.Q*. Efficient production of fluorecent transgenic rats using the piggyback transposon. Scientific Reports. (2016): Doi:10.1038/srep33225.

12. Gu Q, Zhu H, Chen L, Shuai L, Fang J, Wu J, Liu L, Li W, Dai J, Hao J*, Zhou Q*l: Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein Cell (2016), 7(11):844-848.