姓名：陈瑶

学科方向：制剂工程、生物化工、材料学

研究方向：陈瑶课题组长期致力于发展生物大分子固定化平台、新型生物医药材料及相关应用转化（如生物药、新型制剂及生物催化等），并对其生物安全性和相关机制进行深入探讨。主要研究内容：

1．新型生物制剂、酶制剂和生物医药材料的开发（生物药、生物催化、制剂、药物递送等）

2．开发基于生物分子和新型多孔材料的高性能新型分离介质，用于天然产物、手性药物等的高效分离和制备;

3. 基于对蛋白、多肽等生物分子结构和功能的深入解析，进行新型药物及剂型的开发。

4. 面向生物医药、能源等领域，开发新的仿生以及生物催化体系;

通讯地址：天津市海河教育园区同砚路38号，南开大学津南校区综合实验楼B503

电子邮件：chenyao@nankai.edu.cn

导师简介：陈瑶，南开大学药物化学生物学国家重点实验室、药学院教授，博士生导师、国家优青。 2009 年于南京工业大学获硕士学位，2014 年获美国南佛罗里达大学博士学位， 2014 -2016 年在加州大学圣地亚哥分校，从事博士后研究工作。2016 年加入南开大学，创建独立课题组。主持多项国家自然科学基金项目、国家重点研发计划项目课题和企业合作/委托项目。已发表论文100篇及中英文专著2部，近年以第一/通讯作者在包括Nat Protoc、Nat. Rev. Chem.，J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Chem，Adv. Sci.、Adv. Mater.，Chem. Soc. Rev.，ACS Central. Sci., ACS Catal、Adv Healthc Mater，J. Med. Chem.等领域顶刊发表论文46篇（论文篇均影响因子>10），他引超过5600次，10篇论文入选ESI高被引。授权或申请中国发明专利37件、PCT2件、美国发明专利3件；任中国化工学会理事、中国化工学会女科委首届委员、中国生物医药技术协会生物制药技术分会委员、天津市化工学会理事等；任CCL、Particuology、Biodesign Research Engineering in Life Sciences等期刊编委，长期任Nat Catal、J. Am. Chem. Soc.、Nat. Commun.、Adv. Mater.、Chem等学术期刊审稿人，国家自然科学基金委、教育部、科技部通讯评议专家和欧洲研究理事会评审专家。入选天津市高层次人才计划，并获得国家优秀青年科学基金。

部分代表性论文：

1. Haixin Chen#, Chaonan Jin#, Xuepeng Chen, Jiangyue Yu, Peng Cheng, Zhenjie Zhang, Limin Zhao, Yao Chen*, Covalent Organic Frameworks as Crystalline Sponges for Enzyme Extraction and Production from Natural Biosystems. Chem. Eng. J. 2022, https://doi.org/ 10.1016/j.cej.2022.136624.

2. Jinjin Liu, Zhifang Wang, Peng Cheng, Michael J. Zaworotko, Yao Chen*, Zhenjie Zhang*, Post-synthetic modifications of metal–organic cages. Nat. Rev. Chem. 2022, https://doi.org/ 10.1038/s41570-022-00380-y.

3. Zhengfeng Zhao, Dong Zheng, Menglei Guo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang, Yao Chen*, Engineering Olefin-Linked Covalent Organic Frameworks for Photoenzymatic Reduction of CO2. Angew. Chem. Int. Ed. 2022, 61, e202200261.

4. Renhao Yang, Yunlong Zheng, Yin Zhang, Gen Li, Yidong Xu, Yin Zhang, Yang Xu, Chengyu Zhuang, Pei Yu, Lianfu Deng, Wenguo Cui*, Yao Chen*, Lei Wang*, Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal–Organic Framework for Gradient Healing of Tendon-to-Bone Interface Regeneration. Adv. Healthc. Mater. 2022, 2200072.

5. Shan Qiao#, Mingmin Li#, Jiangyue Yu, Sainan Zhang, Dong Yan, Zhenjie Zhang, Yao Chen*, Biomolecule@COF: Natural-artificial hybrid microcapsules for controllable biocatalysis. Particuology 2022, 64, 140-144.

6. Wen Duan#, Shan Qiao#, Mingjing Zhuo, Jiaxing Sun, Menglei Guo, Fei. Xu, Jinjin Liu, Ting Wang, Xiuxiu Guo, Yan Zhang, Jia Gao, Yueyun Huang, Zhenjie Zhang, Peng Cheng, Shengqian Ma*, Yao Chen*, Multifunctional Platforms: Metal-Organic Frameworks for Cutaneous and Cosmetic Treatment. Chem, 2021, 7, 450-462.

7. Zhengfeng Zhao, Yunlong Zheng, Chun Wang, Sainan Zhang, Jie Song, Yafei Li, Shengqian Ma, Peng Cheng, Zhenjie Zhang*, Yao Chen*, Fabrication of Robust Covalent Organic Frameworks for Enhanced Visible-Light-Driven H2 Evolution. ACS Catal. 2021, 11, 2098–2107.

8. Jie Dong, Hong-De An, Ze-Kun Yue, Sheng-Li Hou, Yao Chen*, Zhen-Jie Zhang, Peng Cheng, Qian Peng*, Bin Zhao*, Dual-Selective Catalysis in Dephosphorylation Tuned by Hf6-Containing Metal–Organic Frameworks Mimicking Phosphatase. ACS Cent. Sci. 2021, 7, 831-840.

9. Shan Qiao, Wenjie Duan, Jiangyue Yu, Yunlong Zheng, Dong Yan, Fazheng Jin, Sainan Zhang, Zhenjie Zhang, Haixin Chen, He Huang, Yao Chen*, Fabrication of Biomolecule−Covalent-Organic-Framework Composites as Responsive Platforms for Smart Regulation of Fermentation Application. ACS Appl. Mater. Interfaces 2021, 13, 32058-32066.

10. Wansheng Liu, Yi Yang, Xiaojie Yang, Yun-Lei Peng, Peng Cheng, Zhenjie Zhang*, and Yao Chen*, Template-Directed Fabrication of Highly Efficient Metal–Organic Framework Photocatalysts. ACS Appl. Mater. Interfaces 2021, 13, 58619–58629.

11. Hongde An, Jie Song, Ting Wang, Nannan Xiao, Zhenjie Zhang, Peng Cheng, Shengqian Ma, He Huang, Yao Chen*, Metal-Organic Framework Disintegrants: Enzyme Preparation Platforms with Boosted Activity. Angew. Chem. Int. Ed. 2020, 59, 16764-16769.

12. Mingmin Li, Shan Qiao, Yunlong Zheng, Yassin H. Andaloussi, Xia Li, Zhenjie Zhang, Ang Li, Peng Cheng, Shengqian Ma, Yao Chen*, Fabricating Covalent Organic Framework Capsules with Commodious Microenvironment for Enzymes. J. Am. Chem. Soc. 2020, 142, 6675-6681.

13. Huanrong Wang#, Lin Han#, Dong Zheng, Mingfang Yang, Yassin H. Andaloussi, Peng Cheng, Zhenjie Zhang, Shengqian Ma, Michael J. Zaworotko, Yifan Feng, Yao Chen*, Protein-Structure-Directed Metal-Organic Zeolite-like Networks as Biomacromolecule Carriers. Angew. Chem. Int. Ed. 2020, 59, 6263-6267.

14. Zhifang Wang#, Sainan Zhang#, Yao Chen*, Zhenjie Zhang*, Shengqian Ma*, Covalent Organic frameworks for separation applications. Chem. Soc. Rev. 2020, 9, 708-735（封面）.

15. Yu Zhao, Zhifang Wang, Jia Gao, Zhengfeng Zhao, Xia Li, Ting Wang, Peng Cheng, Shengqian Ma, Yao Chen*, Zhenjie Zhang*, COF-Inspired Fabrication of Two-Dimensional Polyoxometalate Based Open Frameworks for Biomimetic Catalysis. Nanoscale 2020, 12, 21218-21224.

16. Jingjing Dai, Kaipeng Li, Zongjing Feng, Jun Xu, Yao Chen*, Hongbo Zhang*, and Zhenjie Zhang, Evidence on Primary Pore Size Dependence of C–C Bond Coupling Inside Zr-Based Metal–Organic Frameworks. J. Phys. Chem. C 2020, 124, 24713–24722.

17. Juan Xu#, Kaipeng Li#, Sainan Zhang#, Yao Chen*, Lifeng Ning*, Removal of Endocrine-Disrupting Chemicals from Environment Using A Robust Platform Based on Metal–Organic Framework Nanoparticles. ACS Appl. Nano Mater. 2020, 3, 3646−3651.

18. 陈海欣, 张赛男, 赵力民*, 陈瑶*, 固定化酶:从策略到材料设计. 生物加工过程 2020, 18, 87-94.

19. Jinjin Liu, Wenjie Duan, Jie Song, Xiuxiu Guo, Zhifang Wang, Xinlei Shi, Jiajie Liang, Juan Wang, Peng Cheng, Yao Chen*, Michael J. Zaworotko*, Zhenjie Zhang*, Self-Healing Hyper-Cross-Linked Metal–Organic Polyhedra (HCMOPs) Membranes with Antimicrobial Activity and Highly Selective Separation Properties. J. Am. Chem. Soc. 2019, 141, 12064-12070.

20. Zhifang Wang, Qi Yu, Yubo Huang, Hongde An, Yu Zhao, Yifan Feng, Xia Li, Xinlei Shi, Jiajie Liang, Fusheng Pan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, Shengqian Ma*, PolyCOFs: A New Class of Freestanding Responsive Covalent Organic Framework Membranes with High Mechanical Performance. ACS Cent. Sci. 2019, 5, 1352-1359.

21. Yifan Feng, Huanrong Wang, Sainan Zhang, Yu Zhao, Jia Gao, Yunyi Zheng, Peng Zhao, Zhenjie Zhang, Michael J. Zaworotko, Peng Cheng, Shengqian Ma*, Yao Chen*, Antibodies@MOFs: An In Vitro Protective Coating for Preparation and Storage of Biopharmaceuticals. Adv. Mater. 2019, 31, 1805148.（封面论文）

22. Hongde An, Mingmin Li, Jia Gao, Zhenjie Zhang, Shengqian Ma, Yao Chen*, Incorporation of biomolecules in Metal-Organic Frameworks for advanced applications. Coord. Chem. Rev. 2019, 384, 90-106.

23. Cy V. Credille, Yifan Feng, Yao Chen*, Seth Cohen*, SAR Exploration of Tight Binding Inhibitors of Influenza Virus PA Endonuclease. J. Med. Chem. 2019, 62, 9438–9449.

24. Wenjie Duan, Zhengfeng Zhao, Hongde An, Zhenjie Zhang, Peng Cheng, Yao Chen*, He Huang, State of art and prospects of biomolecules-incorporation in functional metal–organic frameworks. Topics Curr. Chem. 2019, 377, 34.

25. Xia Li, Zhifang Wang, Jiaxing Sun, Jia Gao, Yu Zhao, Peng Cheng, Briana Aguila, Shengqian Ma*, Yao Chen*, Zhenjie Zhang*, Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis. Chem. Commun. 2019, 55, 5423-5426.

26. Puge Zhao, Nannan Liu, Chaonan Jin, Jiaxing Sun, Haixin Chen, Zhenjie Zhang*, Limin Zhao*, Peng Cheng, Yao Chen*, UiO-66: An Advanced Platform to Investigate the Influence of Functionalization toward Adsorption Removal of Pharmaceutical Waste. Inorg. Chem. 2019, 58, 8787-8792.

27. Yueyun Huang#, Sainan Zhang#, Haixin Chen, Limin Zhao*, Zhenjie Zhang*, Peng Cheng, Yao Chen*, A Zinc Coordination Complex Mimicking Carbonic Anhydrase for CO2 Hydrolysis and Sequestration. Inorg. Chem. 2019, 58, 9916-9921.

28. Xia Li, Sainan Zhang, Jia Gao, Zhifang Wang, Qi Yu, Yu Zhao, Peng Cheng, Yao Chen*, Zhenjie Zhang*, The recent development and applications of chiral covalent organic frameworks. Sci. Sin. Chim. 2019, 49, 1-9.

29. Sainan Zhang, Yunlong Zheng, Hongde An, Briana Aguila, Chengxiong Yang, Yueyue Dong, Wei Xie, Peng Cheng, Zhenjie Zhang*, Yao Chen*, Shengqian Ma*, Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation. Angew. Chem. Int. Ed. 2018, 57, 16754–16759.

30. Chaonan Jin#, Sainan Zhang#, Zhenjie Zhang*, Yao Chen*, Mimic Carbonic Anhydrase Using Metal-Organic Frameworks for CO2 Capture and Conversion. Inorg. Chem. 2018, 57, 2169-2174.

31. Yao Chen*, Seongmin Hong, Chung-Wei Fu, Tran Hoang, Xiao Li, Veronica Valencia, Zhenjie Zhang, Jason A. Perman, Shengqian Ma*, Investigation of Mesoporous Metal-Organic Framework as a new study the Transport phenomena of Biomolecules. ACS Appl. Mater. Interfaces 2017, 9, 10874-10881.

32. Yao Chen, Lukasz Wojtas, Shengqian Ma, Michael J. Zaworotko*, Zhenjie Zhang*, Post-synthetic transformation of a Zn(II) polyhedral coordination network into a new supramolecular isomer of HKUST-1. Chem. Commun. 2017, 53, 8866-8869.

33. Yao Chen*, Barry Lai, Zhenjie Zhang, Seth M. Cohen*, The effect of metalloprotein inhibitors on cellular metal ion content and distribution. Metallomics, 2017, 9, 250-257.

34. Yao Chen, Shengqian Ma*, Biomimetic catalysis of metal-organic frameworks. Dalton Trans. 2016, 45, 9744-9753.

35. Yao Chen, Seth M. Cohen*, Investigation the Selectivity of Metalloenzyme Inhibitors in the Presence of Competing Metalloproteins. ChemMedChem, 2015, 10, 1733-1738.

36. Yao Chen, Sungyub Han, Xiao Li, Zhenjie Zhang, Shengqian Ma*, Why Does Enzyme Not Leach from Metal–Organic Frameworks (MOFs)? Unveiling the Interactions between an Enzyme Molecule and a MOF. Inorg. Chem. 2014, 53, 10006-10008.

37. Yao Chen, Vasiliki Lykourinou, Carissa Vetromile, Tran Hoang, Li-June Ming, Randy W. Larsen, Shengqian Ma*, How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows. J. Am. Chem. Soc. 2012, 134, 13188-13191.

38. Yao Chen, Tran Hoang, Shengqian Ma*, Biomimetic Catalysis of a Porous Iron-Based Metal–Metalloporphyrin Framework. Inorg. Chem. 2012, 51, 12600–12602.

39. Yao Chen, Vasiliki Lykourinou, Xi-Sen Wang, Tran Hoang, Li-June Ming, Shengqian Ma*, Size-Selective Biocatalysis of Myoglobin Immobilized into a Mesoporous Metal-Organic Framework with Hierarchical Pore Sizes. Inorg. Chem. 2012, 51, 9156-9158.

40. Yao Chen, Shengqian Ma*, Microporous Lanthanide Metal-Organic Frameworks. Rev. Inorg. Chem. 2012, 32, 81-100.

41. Vasiliki Lykourinou#, Yao Chen#, Xi-Sen Wang, Le Meng, Tran Hoang, Li-June Ming*, R. L. Musselman, Shengqian Ma*, Immobilization of MP-11 into a mesoporous metal–organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis. J. Am. Chem. Soc. 2011, 133, 10382-10385.

陈瑶课题组紧密结合当前生物医药及生物化工领域的前沿科学问题，发展具有重大应用转化前景的特色体系。欢迎具有饱满科研热情和蓬勃创造力的相关专业青年才俊（博后、博士、硕士、本科、研究助理）加入我们欣欣向荣的交叉学科团队！课题组诚聘师资博士后和研究助理等各层次人才，发展平台好、待遇优厚，欢迎联系!（chenyao@nankai.edu.cn）