FacultyProfessor
Luyuan Li

Luyuan Li, PhD

Professor of Pharmacology, College of Pharmacy

Director, State Key Laboratory of Medicinal Chemical Biology

Nankai University, Tianjin, China

Research Interests: Vascular Biology and Cancer Microenvironment

Team Members: Zhisong Zhang Associate Professor, Qiangzhe Zhang Lecturer

Phone: 022-23502797

Email: liluyuan@nankai.edu.cn 

Address: State Key Laboratory of Medicinal Chemical Biology, Nankai University, 38 Tongyan Road, Tianjin 300350, China

Luyuan Li obtained a BS degree in Biochemistry from Sichuan University, Chengdu, China, in 1982, and a PhD degree from Cornell University, New York, the United States in 1988, also in Biochemistry. Having completed his postdoctoral training at Pennsylvania State University, he joined American Cyanamid Company in New York in 1991 as a Senior Scientist. He moved back to academia to join the faculty of Georgetown University Medical Center, Washington, DC, in 1995, as an Assistant Professor of Biochemistry and Molecular Biology, and a Member of the Lombardi Cancer Center. He moved to University of Pittsburgh School of Medicine in 2002 as an Associate Professor of Pathology, Member of the University of Pittsburgh Cancer Institute, and Member of McGowan Institute for Regenerative Medicine. He moved his laboratory to China in 2008 and joined the faculty of Nankai University, Tianjin. He is currently a Professor of Pharmacology in the College of Pharmacy, and Director of the State Key Laboratory of Medicinal Chemical Biology at Nankai University.

Research in Li laboratory has focused on vascular cell biology. Currently there are two projects on going in his lab. One project deals with the role of tumor necrosis factor superfamily 15 (TNFSF15; a.k.a vascular endothelial growth inhibitor, VEGI) in the regulation of neovascularization and the maintenance of vascular homeostasis. The other project concerns a newly identified human gene, rhomboid family-1 (RHBDF1), which plays a critical role in the regulation of new blood vessel growth under hypoxic conditions. He has published 59 original research articles and review articles in PNAS USA, Blood, JBC, FASEB J, Circulation Res, Cancer Res, J Immunol, Cell Res, J Pathol, and Angiogenesis, among others, with a total 2338 citations (1099 since 2010), highest single paper 208 citations, h-Index 25 (19 since 2010). 

Selected Publications:

1. Zhai, Y, Ni, J, Jiang, GW, Lu, J, Xing, L, Lincoln, C, Janat, F, Kozak, D, Rojas, L, Aggarwal, BB, Ruben, S, Li, LY, Gentz, R, and Yu, GL. VEGI, a novel cytokine of the TNF family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J. 13: 181-189, 1999

2.  Zhai, Y, Yu, JY, Iruela-Arispe, L, Huang, WQ, Wang, Z, Hayes, AJ, Lu, J, Jiang, GW, Rojas, L, Lippman, ME, Ni, J, Yu, GL, and Li, LY*. Inhibition of Angiogenesis and Breast Cancer Xenograft Tumor Growth by VEGI, a Novel Cytokine of the TNF Superfamily. Int. J. Cancer 82:131-136, 1999

3. Hayes, AJ, Maisonpierre, P, Huang, WQ, McLeskey, S, Kern, F, Lippman, ME, and Li, LY*. Expression and function of angiopoietin-1 in breast cancer. Brit. J. Cancer 83:1154-1160, 2000

4.  Yu, JY, Tian, S, Metheny-Barlow, L, Chew, LJ, Hayes, A, Huang, WQ, Pan HG, Yu, GL, and Li, LY*. Modulation of Endothelial Cell Growth Arrest and Apoptosis by Vascular Endothelial Growth Inhibitor. Circulation Res. 89:1161-1167, 2001

5. Tian, S, Hayes, AJ, Metheny-Barlow, L, and Li, LY*. Stabilization of breast cancer xenograft tumor neovasculature by angiopoietin-1. Brit. J. Cancer 86:645-651, 2002

6.  Chew, LJ, Pan, HG, Yu, J, Tian, S, Huang, WQ, Zhang, JY, Pang, S, and Li, LY*. A novel secreted splice variant of vascular endothelial cell growth inhibitor. FASEB J, 16:742-4, 2002

7.  Metheny-Barlow, LJ, Li LY*. The enigmatic role of angiopoietin-1 in tumor angiogenesis. Cell Res. 13:309-17, 2003

8.  Hou, W, Medynski, D, Wu, S, Lin, XL, Li, LY*. VEGI-192, a New Isoform of TNFSF15, Specifically Eliminates Tumor Vascular Endothelial Cells and Suppresses Tumor Growth. Clinical Cancer Res. 11:5595-5602, 2005

9.  Tian, F, Grimaldo, S, Mitssugu, F, Cutts, J, Vujanovic, NL, and Li, LY*. The Endothelial Cell-Produced Anti-Angiogenic Cytokine Vascular Endothelial Growth Inhibitor (VEGI) Induces Dendritic Cell Maturation. J. Immunol. 179:3742-51, 2007

10. Yan, ZW, Zou, HF, Tian, F, Grandis, JR, Mixson, AJ, Lu, PY, and Li, LY*. Human Rhomboid Family-1 (RHBDF1) Gene-Silencing Causes Apoptosis or Autophagy to Epithelial Cancer Cells and Inhibits Xenograft Tumor Growth. Mol. Cancer Therap. 7:1355-64, 2008

11.  Zou, H, Thomas, SM, Yan, ZW, Grandis, JR, Vogt, A, and Li, LY*. Human Rhomboid Family-1 Gene RHBDF1 Participates in GPCR-Mediated Transactivation of EGFR Growth Signals in Head and Neck Squamous Cancer Cells. FASEBJ, 23:425-432, 2009

12.  Tian, F, Liang, PH, and Li, LY*. Inhibition of endothelial progenitor cell differentiation by VEGI. Blood, 113:5352-536, 2009

13.  Grimaldo, S, Tian, F, and Li, LY*. Sensitization of endothelial cells to VEGI-induced apoptosis by inhibiting the NF-κB pathway. Apoptosis. 14:788-795, 2009

14. Xiao T, Fan JK, Huang HL, Gu JF, Li, LY*, Liu XY. VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis. Cell Res. 2010 Mar;20(3):367-78

15. Liang PH, Tian F, Lu Y, Duan B, Stolz DB, Li, LY*. Vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis lung carcinoma tumors. Angiogenesis. 2011 Mar;14(1):61-8

16. Deng W, Gu X, Lu Y, Gu C, Zheng Y, Zhang Z, Chen L, Yao Z, Li, LY*. Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization. Angiogenesis, 2012: p. 1-15.

17.Zhang Q, Lu Y, Ding Y, Zhai J, Ji Q, Ma W, Yang M, Fan H, Long J, Tong Z, Shi Y, Jia Y, Han B, Zhang W, Qiu C, Ma X, Li Q, Shi Q, Zhang H, Li D, Zhang J, Lin J, Li, LY, Gao Y, Chen Y, Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem, 2012. 55(20):8757-69.

18. Zhang Z, Li, LY*. TNFSF15 Modulates Neovascularization and Inflammation. Cancer Microenviron. 2012 Dec;5(3):237-47.

19.Lu Y, Zhang Z, Yan Z, Chen L, Deng W, Lotze M, Wang Z, Lin X, Li LY*. Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo. Apoptosis. 2013 Oct;18(10):1214-23.

20. Y Lu, X Gu, L Chen, Z Yao, J Song, X Niu, R Xiang, T Cheng, Z Qin, W Deng, LY Li*. Interferon-γ produced by tumor-infiltrating NK cells and CD4  T cells downregulates TNFSF15 expression in vascular endothelial cells. Angiogenesis, 2014 Jul;17(3):529-40.

21.JW Qi, TT Qin, LX Xu, K Zhang, GL Yang, J Li, HY Xiao, ZS Zhang, LY Li* . TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. PNAS, 2013. 110 (34), 13863-13868

22.Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X, Xiang R. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat Commun. 2014 Jun 27;5:4280.

23. Zhou Z, Liu F, Zhang ZS, Shu F, Zheng Y, Fu L*, Li LY*. Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1α in breast cancer. Cancer Res. 2014 May 15;74(10):2719-30.

24.Xu LX, Grimaldo S, Qi JW, Yang GL, Qin TT, Xiao HY, Xiang R, Xiao Z, Li LY*, Zhang ZS*. Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis. Int J Biochem Cell Biol. 2014 Oct;55:109-18.

25.Yang Z, Wu W, Wang J, Liu L, Li L, Yang J, Wang G, Cao D, Zhang R, Tang M, Wen J, Zhu J, Xiang W, Wang F, Ma L, Xiang M, You J, Chen L. Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. J Med Chem. 2014 Oct 9;57(19):7977-89.

26.Qin T, Xu G, Qi J, Yang G, Zhang K, Liu H, Xu L, Xiao G, Cao H, Wei Y, Zhang Q, Li L*. Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol. 2015, DOI: 10.1002/path.4577.


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