Wei Zhao

Dr. Wei Zhao, Professor of Medicinal Chemistry

Research Interests: Glycobiology, Medicinal Chemistry, Chemical Biology

Phone: 86-22-85358558

Email:  wzhao@nankai.edu.cn

Address: College of Pharmacy, Nankai University, China

Dr. Wei Zhao obtained his BS in Chemistry (1999) from Shandong University and his Ph.D. in Environmental Chemistry (2005) from the Research Center for Eco-Environmental Sciences (RCEES), CAS, Beijing. After he held postdoctoral fellowships at the Department of Chemistry, Tsinghua University with Prof. Yanmei Li in 2007, Dr. Zhao moved to the College of Pharmacy at Nankai University. As a visiting scholor, he worked at the Department of Biochemistry, The Ohio State University with Prof. Peng G. Wang in 2009, and the Center for Cancer Research at Frederick, National Cancer Institute in 2010. He is currently an associate professor in the College of Pharmacy at Nankai University. His research interests include glycoscience with an emphasis on carbohydrate chemistry, glycopharmaceutical science, carbohydrate-based vaccines, drugs and immunotherapy, as well as the structural and mechanism-based design and synthesis of inhibitors and ligands.


1.  Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang and Wei Zhao*, “Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.

2.     Yonghui Liu, Tianbang Song, Weijia Meng, Yun Xu, Peng George Wang, Wei Zhao*,“Hafnium(IV) triflate as a highly efficient catalyst for Ferrier rearrangement of O- and S-nucleophiles with glycals”, Tetrahedron Letters. 2016, 25,2758–2762.

3.  Jiajia Wang, Xiaomin Wang, Yunyan Zhao, Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, Peng George Wang and Wei Zhao*,“Synthesis and biological evaluation of D-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease”, Med. Chem. Commun, 2016, 7, 365.

4. Wenjun Wang, Zhongyue Yang, Yun Xu, Taibao Liu, Tianbang Song, Yunyan Zhao, Xiufang Xu*, Wei Zhao* and Peng George Wang*, ““Armed and disarmed” theory in the addition of an azide radical to glucals”, RSC Advances, 2015, 5, 38577 - 38580.

5. Yun Xu, Wenjun Wang, Yu Cai, Xia Yang,Peng George Wang and Wei Zhao*, “A convenient and efficient synthesis of glycals byzinc nanoparticles”, RSC Advances, 2014, 4 , 46662 - 46665.

6. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic & Biomolecular Chemistry, 2014, 12, 7310–7317.

7. Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, and Peng Wang*, “Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.

8. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao*, and Peng George Wang*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.

9. Lina Guo, Yonghui Liu, Yue Wan, Peng George Wang and Wei Zhao*,“Effective and one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanes for the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54,2579-2582.

10. Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang*, Wei Zhao*, “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & Medicinal Chemistry Letters. 22 (2012) 6854-6857.

11. Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*, and Peng Wang*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012, 355C, 34-38.

12. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*,“Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in Medicinal Chemistry. 2012, 12, 1533-1541. 

13. Wenjun Wang, Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang, Lei Li, Wei Zhao*, Peng George Wang*,“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242. 

14. Wenjun Wang, Lei Li, Chen Jin, Yujie Niu, Sen Li, Ji Ma, Linfeng Li, Yu Liu, Li Cai, Wei Zhao*, Peng George Wang*,“Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support.” Bioorganic & Medicinal Chemistry Letters. 2011, 17, 5041-5044.

15. Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang , Lei Li, Jianping Lin, Wei Zhao*, Jing Li*and Peng George Wang*, “Design and synthesis of O-GlcNAcase inhibitors via Click Chemistry and biological evaluations.”Carbohydrate Research. 346 (2011) 1083-1092.

16. Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao* and Peng George Wang* , “Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136-2144.

Book Edition

Wei Zhao, Tiehai Li, Robert Woodward, Chengfeng Xia, Peng George Wang and Wanyi Guan. “Enzymatic Synthesis of Complex Carbohydrates”. Comprehensive Natural Products Chemistry II. Volume 6. Elsevier 2010, 5-54.

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