Jianping Lin

Jianping Lin

College of Pharmacy, Nankai University, Tianjin, China

Emailjianpinglin@nankai.edu.cn Phone:  022-23506290   


2000.8 – 2005.8            Duke University, Durham, NC

Ph.D.                           in Theoretical Biophysics and Biochemistry

Advisor:                       Prof. David N. Beratan

1997.8– 2000.7            Beijing University, Beijing, China

M.S.                            in Polymer Chemistry

Advisor:                       Prof. Gaoyuan Wei

1992.8 – 1997.7           Beijing University, Beijing, China

B.S.                             in Chemistry  

Advisor:                       Prof. Gaoyuan Wei  

Working Experience

2009.12-            Professor, College of Pharmacy, Nankai University

2006.3- 2009.11 Research Fellow    City of Hope National medical Center

2005.9-2006.2    Research associate                    Duke University

Research Interests

Computer-aided drug design;

Simulations of bio-systems including GPCRs, DNA nanostructures, viral proteins; 

Computer-aided (redox) enzyme design                


1.Meng H, Liu P, Sun H, Cai Z, Zhou J*, Lin J*, Yin Li*, Engineering a d-lactate dehydrogenase that can super- efficiently utilize NADPH and NADH as cofactors, Scientific Reports 2016, 6, 24887, DOI: 10.1038/srep24887.

2.Wang Z, Liang L, Yin Z, Lin J*, Improving chemical similarity ensemble approach in target prediction, Journal of Cheminformatics, 2016, 8:20, DOI 10.1186/s13321-016-0130-x.

3.Li Y, Sun J, Li D*, Lin J*, Activation and conformational dynamics of a class B G-protein-coupled glucagon receptor, Phys. Chem. Chem. Phys. 2016, 18, 12642—12650.

4.Wei Y, Li J, Qing J, Huang M , Wu M, Gao F , Li D , Hong Z, Kong L*, Huang W*, Lin J*, Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking. PLoS ONE 2015, 11(2): e0148181. doi:10.1371/journal.pone.014818.

5.Guo Q , Wei Y, Xia B , Jin Y, Liu C, Pan X, Shi J, Zhu F, Li J, Qian L, Liu X, Cheng Z , Jin S* , Lin J*, Wu W*, Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa. Scientific Reports 2016, 6:19141, DOI: 10.1038/srep19141.

6. Han L, Liu P, Sun J, Wu Y, Zhang Y, Chen W, Lin J*, Wang Q*, Ma Y.   Engineering catechol 1, 2-dioxygenase activity by rational design for improving the performance of muconic acid synthetic pathway in Escherichia coli .   Scientific Reports 2015, 5:13435, DOI: 10.1038/srep13435

7.Liu P, Wang Z, Zhang L, Li D*, Lin J* The Mechanism by which 146-N-Glycan Affects the Active Site of Neuraminidase  Plos one, 2015, 10(8): e0135487. doi:10.1371/journal.pone.0135487.

8.XU J, Wang Z, Liu P, Li D*, Lin J*, Insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1, Mol. Biosyst. 2015,11,2042-2050.

9.Huo T, Liu W, Guo Y, Yang C, Lin J*, Rao Z, Prediction of host-pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs BMC Bioinformatics 2015, 16:100.

10.Wang Z, Li J, Dang R, Liang L, Lin J*, PhIN: a protein pharmacology interaction network database. CPT Pharmacometrics Syst. Pharmacol. 2015, 4, 160-166.

11.Li D*, Liu C, Lin J*, Theoretical study of the mechanism of protein arginine deiminase 4(PAD4) inhibition by F-amidine. J Mol. Graphics Model. 2015, 55, 25-32.

12.Han L, Liu P, Shuler P, Tang Y, Lin J*, Wang Q*, Ma Y. Engineering the biosynthesis of novel rhamnolipids in Escherichia coli for enhanced oil recovery. J. Applied Mircobio. 2014, 117,139-150.

13.Yan Z, Zhang L, Fu H, Wang Z, Lin J*, Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking. BMCL 2014, 24, 539-547.

14.Sang F,Feng P,Chen J,Ding Y,Duan X, Zhai J, Ma X, Zhang B, Zhang Q, Lin J*, Chen Y* Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities. Euro. J. Med. Chem. 2013, 68, 321e332.

15.Huo T, Zhang YJ, Lin J*. Functional annotation from the genome sequence of the giant panda. Protein & Cell 2012,3(8),602-608.

16.Lin J*, Liu P, Yang HZ, Vaidehi N*. Factors That Affect the Computational Prediction of Hot Spots in Protein-Protein Complexes, Comput. Mole. Sci. 2012, 2, 23-34.

17.Lin J, Buettner R, Yuan YC, Yip R, Horne D, Jove R, Vaidehi N. Molecular dynamics simulations of the conformational changes in Signal Transducers and Activators of Transcription, Stat1 and Stat3. J Mol Graph Model. 2009 Nov,28(4),347-56.

18. Lin J; Seeman NC; Vaidehi N, “Molecular dynamics simulations of insertion of chemically modified DNA nanostructures into water-chloroform interface”  Biophys. J. 2008, 95, 1099-1107.

19.Sung JC; Lin J, Diamond Nanotechnology: Synthesis and applications. Pan Stanford Publishing, 2009.

20.Lin J; Buettner R, Yuan YC, Yip R, Horne D, Jove R, Vaidehi N“Molecular dynamics simulations of the conformational changes in Signal Transducers and Activators of Transcription, Stat1 and Stat3” J. Mole. Graphics Model. 2009, 28,347-356 .

21.Lin J; Balabin IA; Beratan DN, “The Nature of Aqueous Tunneling Pathways between Electron-transfer Proteins”   Science  2005, 310,1311-1313.   related news: “Water can ease electron transfer between proteins” Chemical & Engineering News   November 28, 2005. Page 11.

22.Lin J; Beratan DN “Simulation of Electron transfer between Cytochrome c2 and the Bacterial Photosynthetic Reaction Center: Brownian Dynamics Analysis of the Native Proteins and Double Mutants.”   J. Phys. Chem. B 2005, 109, 7529-7534.

23.Jianping Lin; David N. Beratan "Tunneling while Pulling: The Dependence of Tunneling Current on End-to-End Distance in a Flexible Molecule."  J. Phys. Chem. A 2004, 108, 5655-5661.

24.Skourtis SS; Lin J; Beratan DN “The Effects of Bridge Motion on Electron Transfer Reactions Mediated by Tunneling” Chapter 18 in Modern Methods for Theoretical Physical Chemistry of Biopolymers. Edited By E. B. Starikov; S. Tanaka; J. P. Lewis, Elsevier Press, June 2006.


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