Yao Chen

Yao Chen, PhD

Senior Research Fellow, State Key Laboratory of Medicinal Chemical Biology

College of Pharmacy, Nankai University, Tianjin, China

Study and work experience:

2002-2006, B.S. in Pharmaceutical Engineering, Qingdao University of Science and Technology, China,

2006-2008, M.S. in Microbiology, Nanjing University of Technology, China,

2008-2010, M.S. in Chemical Engineering, Ohio University, USA,

2011-2014, Ph.D. in Chemistry, University of South Florida, USA)

2014.7-2016.7,UC San Diego, department of chemistry and biochemistry, postdoctoral fellow

Research contents:

Research in Chen laboratory has focused on: Gene, protein and small molecule drug delivery; Development of novel antimicrobial material and antibiotic; Discovery and evaluation of metalloprotein inhibitors; The biomedical and biocatalysis application of porous materials. She has published original research articles in J. Am. Chem. Soc., Angew. Chem., J. Med. Chem., ChemMedChem, and Inorg. Chem. among others.

1. Fermentation to produce multifunctional peptide vectors as novel and high efficient gene/protein/small-molecule drug delivery system

2. Using metalloprotein inhibitors as targets, developing antibiotics and antimicrobial agents through Fragment-based drug discovery strategy

3. Investigating the influence of environment pollution towards cellular metal homeostasis using elemental mapping

4. Biomimetic and biocatalysis application of porous materials, e.g. Metal-Organic Framework

Selected Publications:

1. Immobilization of MP-11 into a mesoporous metal–organic framework, MP-11@ mesoMOF: a new platform for enzymatic catalysis;Journal of the American Chemical Society;133,10382-10385;Vasiliki Lykourinou,# Yao Chen,# Xi-Sen Wang, Le Meng, Tran Hoang, Li-June Ming,* Ronald L Musselman, Shengqian Ma*   (#共同一作)

2. How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows;Journal of the American Chemical Society;134,13188-13191;Yao Chen, Vasiliki Lykourinou, Carissa Vetromile, Tran Hoang, Li-June Ming, Randy W Larsen, Shengqian Ma*

3. Biomimetic catalysis of a porous iron-based metal–metalloporphyrin framework;Inorganic chemistry;51,12600-12602;Yao Chen, Tran Hoang, Shengqian Ma*     

4. Size-selective biocatalysis of myoglobin immobilized into a mesoporous metal–organic framework with hierarchical pore sizes;Inorganic chemistry;51,9156-9158;Yao Chen, Vasiliki Lykourinou, Tran Hoang, Li-June Ming, Shengqian Ma*  

5. Investigating the Selectivity of Metalloenzyme Inhibitors in the Presence of Competing Metalloproteins; ChemMedChem; 10, 1733-1738; Yao Chen and Seth Cohen

6. Why Does Enzyme Not Leach from Metal–Organic Frameworks (MOFs)? Unveiling the Interactions between an Enzyme Molecule and a MOF;Inorganic chemistry;53,10006-10008;Yao Chen, Sungyub Han, Xiao Li, Zhenjie Zhang, Shengqian Ma*


Polyhedral cage-containing mesoporous metal-organic frameworks as platform for biocatalysis, methods of making these frameworks, and methods of using these frameworks ,US9404105B2

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