Chenggang Li

Chenggang Li, PhD

Senior Research Fellow, 

State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy, Nankai University, Tianjin, China

Chenggang Li obtained a BS and MS degree in Harerbin Medical University, Haerbin, China, in 2007, and a PhD degree from Peking Union Medical College, Beijing, in 2010, in Biochemistry and Molecular Biology. Started his postdoctoral training at Harvard Medical School and Brigham and Women’s Hospital in Boston, Massachusetts 2011. He joined Nankai University, Tianjin in 2016 and currently a Senior Research Fellow of the State Key Laboratory of Medicinal Chemical Biology at Nankai University.

Research in Li laboratory has focused on cancer biology. Currently the major project on going in his lab is focusing on the role of abnormal lipid metabolic signatures on tumorigenesis and the potential of biomarkers. The pathway identified by Li is prostaglandin biosynthesis pathway dominates by loss of TSC, a tumor suppressors, in a female predominant rare disease of LAM. Which plays a critical role in the regulation of tumor cell growth, anti-apoptosis and metastasis. He has published original research articles and review articles in JEM, Cell Res, Red Journal, and JMCB, among others.

Selected Publications:

1.Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, Meng J, Chen X, Li L, Li D, Xu H, Wang H, Li B, Jiang C. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway Journal of molecular cell biology 1 (1): 37-45

2.Yang P, Deng J, Li C (co-first author), Zhang P, Xing L, Li Z, Wang W, Zhao Y, Yan Y, Gu H, Liu X, Zhao Z, Zhang S, Wang X, Jiang C. Characterization of the 2009 pandemic A/Beijing/501/2009 H1N1 influenza strain in human airway epithelial cells and ferrets. PLoS One. 7(9):e46184.

3.Sun Y, Li C (co-first author), Shu Y, Ju X, Zou Z, Wang H, Rao S, Guo F, Liu H, Nan W, Zhao Y, Yan Y, Tang J, Zhao C, Yang P, Liu K, Wang S, Lu H, Li X, Tan L, Gao R, Song J, Gao X, Tian X, Qin Y, Xu KF, Li D, Jin N, Jiang C.  Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection. Science Signaling 5 (212): ra16

4.Li C, Yang P, Sun Y, Li T, Wang C, Wang Z, Zou Z, Yan Y, Wang W, Wang C, Chen Z, Xing L, Tang C, Ju X, Guo F, Deng J, Zhao Y, Yang P, Tang J, Wang H, Zhao Z, Yin Z, Cao B, Wang X, Jiang C. IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus. Cell research 22 (3): 528-538

5.Li C, Yang P, Zhang Y, Sun Y, Wang W, Zou Z, Xing L, Chen Z, Tang C, Guo F, Deng J, Zhao Y, Yan Y, Tang J, Wang X, Jiang C. Corticosteroid treatment ameliorates acute lung injury induced by 2009 swine origin influenza A (H1N1) virus in mice. PLoS One. 7(8):e44110.

6.Li C, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, Morrison TA, Silverman EK, Henske EP, Yu JJ. Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology 49 (1):135-142

7.Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153(4):840-54.

8.Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of experimental medicine 211 (1):15-28

9.Li C, Zhang E, Sun Y, Lee PS, Zhan Y, Guo Y, Osorio JC, Rosas IO, Xu KF, Kwiatkowski DJ, Yu JJ. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis complex and lymphangioleiomyomatosis. PLoS ONE 9 (10): e104809

10.Sun Y, Guo F, Zou Z, Li C (co-first author),  Hong X, Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao J, Mo Z, Li D, Li B, Li Q, Zhong N, Wang C, Penninger JM, Jiang C. Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Particle and Fibre Toxicology 12 (4)

11.Li C, Li N, Liu X, Zhang E, Sun Y, Masuda K, Li J, Sun J, Morrison T, Li X, Chen Y, Wang J, Karim N, Zhang Y, Blenis J, Reginato M, Henske E and Yu J. Proapototic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. JCI insight. 2016 (Accepted)

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