FacultyProfessor
Zhongbo Yu

Zhongbo Yu, Principle investigator

Research Interests: Single-molecule/cell biophysics, Macromolecule interactions, Drug discovery, Leukemia, Instrumentation

Phone: 15902202134

Emailzyu@nankai.edu.cn

Address: College of Pharmacy, Nankai University, 38 Tongyan Road. Tianjin 300350, China

Zhongbo Yu finished his bachelor’s degree in medicine from Tongji Medical College, Huazhong University of Science & Technology, in 2001. He later graduated with his master’s degree in medicine from Zhejiang Academy of Medical Sciences in 2007. He received his PhD degree in Chemistry from Kent State University in US in 2013. After the postdoctoral training in single-molecule biophysics in Delft University of Technology in the Netherlands, he came to Nankai University in 2015. He dedicated his effort to understand the molecular mechanisms underlying the cancer of leukemia and design knowledge-based new drugs. Using the most up-to-date single-molecular tools, his crew of multidisciplinary performs the state-of-the-art experiments on the macromolecular interactions of DNA, RNA, and proteins. His team also develops novel instruments to solve the most pressing problems in the front of the cancer research. Zhongbo’s group is open to international members who would like to share their knowledge and develop their own expertise motivated by their own interests. 

Selected Publications

1.  Yu Z, Dulin D, Cnossen J, K?ber M, van Oene MM, Ordu O, Berghuis BA, Hensgens T, Lipfert J, Dekker NH. A force calibration standard for magnetic tweezers. Rev Sci Instrum. 2014 Dec;85(12):123114. doi: 10.1063/1.4904148. PubMed PMID:25554279.

2. Yu Z, Cui Y, Selvam S, Ghimire C, Mao H. Dissecting cooperative communications in a protein with a high-throughput single-molecule scalpel. Chemphyschem. 2015 Jan 12;16(1):223-32. doi: 10.1002/cphc.201402443. Epub 2014 Dec 2. PubMed PMID: 25470139.

3. Yu Z, Selvam S, Mao H. Intermediates stabilized by tryptophan pairs exist in trpzip Beta-hairpins. Biochemistry. 2014 Sep 30;53(38):5978-86. doi: 10.1021/bi500194g. Epub 2014 Sep 17. PubMed PMID: 25164564.

4.  Yu Z, Mao H. Non-B DNA structures show diverse conformations and complex transition kinetics comparable to RNA or proteins--a perspective from mechanical unfolding and refolding experiments. Chem Rec. 2013 Feb;13(1):102-16. doi: 10.1002/tcr.201200021. Epub 2013 Feb 6. PubMed PMID: 23389854.

5. Yu Z, Koirala D, Cui Y, Easterling LF, Zhao Y, Mao H. Click chemistry assisted single-molecule fingerprinting reveals a 3D biomolecular folding funnel. J Am Chem Soc. 2012 Aug 1;134(30):12338-41. doi: 10.1021/ja303218s. Epub 2012 Jul 24. PubMed PMID: 22799529.

6. Yu Z, Gaerig V, Cui Y, Kang H, Gokhale V, Zhao Y, Hurley LH, Mao H. Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events. J Am Chem Soc. 2012 Mar 21;134(11):5157-64. doi: 10.1021/ja210399h. Epub 2012 Mar 9. PubMed PMID: 22372563; PubMed Central PMCID: PMC3336359.

7. Yu Z, Schonhoft JD, Dhakal S, Bajracharya R, Hegde R, Basu S, Mao H. ILPR G-quadruplexes formed in seconds demonstrate high mechanical stabilities. J Am Chem Soc. 2009 Feb 11;131(5):1876-82. doi: 10.1021/ja806782s. PubMed PMID: 19154151.

 



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