FacultyProfessor
Xinyi Lu

Xinyi Lu, Principle Investigator

Research Interests: Functional Genomics, RNA biology, Stem Cell Biology and Aging

Phone: 022-23495191

Emailluxy@nankai.edu.cn

Address: State Key Laboratory of Medicinal Chemical Biology, Nankai University, 38 Tongyan Road, Tianjin 300350, P.R.China

Dr. Lu received his Ph. D. in Biological Sciences from National University of Singapore in 2013. Afterwards, he did his post-doctoral training in Genome Institute of Singapore. In 2015, he joined State Key Lab of Medicinal Chemical Biology and College of Pharmacy, Nankai University. He has published on world-renowned scientific journals such as Nature Cell Biology, Nature Structural & Molecular Biology, and Cell Stem Cell. His current research interests lie on applying functional genomics to study stem cell biology and aging-related diseases.

Selected Publications:

1.  Jonathan G?ke#, Xinyi Lu,Yun-Shen Chan, Huck-Hui Ng, Lam-Ha Ly, Friedrich Sachs, Iwona Szczerbinska. Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells. Cell Stem Cell, 2015 Feb; 16(2):135-141.

2.  Xinyi Lu, Huck-Hui Ng, and Paula A. Bubulya#.The role of SON in splicing, development, and disease. Wiley Interdisciplinary Reviews: RNA.2014 Sep;5(5):637-46.

3.  Xinyi Lu, Friedrich Sachs, LeeAnn Ramsay, Pierre-?tienne Jacques, Jonathan G?ke, Guillaume Bourque#& Huck-Hui Ng#. The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature Structural & Molecular Biology. 2014 Apr;21(4):423-5.

4.  Xinyi Lu*, Jonathan G?ke*, Friedrich Sachs, Pierre-?tienne Jacques, Hongqing Liang, Bo Feng, Guillaume Bourque, Paula A. Bubulya, Huck-Hui Ng#. SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nature Cell Biology. 2013 Oct;15(10):1141-52.

5.   Na-Yu Chia*, Yun-Shen Chan*, Bo Feng*, Xinyi Lu, Yuriy L. Orlov, Dimitri Moreau, Pankaj Kumar, Lin Yang, Jianming Jiang, Mei-Sheng Lau, Mikael Huss, Boon-Seng Soh, Petra Kraus, Pin Li, Thomas Lufkin, Bing Lim, Neil D. Clarke, Frederic Bard#& Huck-Hui Ng#. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature. 2010 Nov; 468(7321); 316-20.  (* equal contribution; #Correspondance)



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